FORMULATION AND EVALUATION OF SUSTAINED RELEASE LIQUISOLID TABLETS OF METOPROLOL SUCCINATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3
Abstract
Liquisolid technique is the novel concept of drug delivery via the oral route. This technique is applied to poorly water soluble, water insoluble or liphophilic drugs. According to the new formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. The present research endeavor is directed towards the development of liquisolid compact for the production of sustained release tablet of water-soluble Metoprolol succinate. Liquisolid compacts were prepared by using Tween 80 as the liquid vehicle or non-volatile solvent, Avicel PH 102 as absorbing carrier and Aerosil 200 as adsorbing coating material. The prepare dliquisolid systems were evaluated for their micromeretic properties and possible drug-excipients interactions. P-XRD analysis confirmed that no change in crystallinity of Metoprolol succinate Liquisolid compacts. The DSC and IR spectra analysis study ruled out no any significant interaction between the drug and excipients used in preparation of Metoprolol succinate Liquisolid compacts. The tableting properties were falling within acceptable limits. The in vitro dissolution study confirmed reduction in drug release from Liquisolid compacts compared to conventional matrix tablet, in-vivo study was carried out to check the plasma drug concentration. Tween 80 has plasticizer effect by which it can reduce the glass transition temperature of polymer and impart flexibility in sustaining the release of drug from liquisolid matrices. The results showed that wet granulation had a remarkable impact on the release rate of Metoprolol succinate from liquisolid compacts, reducing the release rate of drug from liquisolid compacts.
Authors and Affiliations
Ravindra Jarag , Akash Rathod , Renuka Salunkhe , Manoj Mangal
Keywords
Related Articles
- EP ID EP103988
- DOI 10.7897/2230-8407.04342
- Views 116
- Downloads 0
FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF VENLAFAXINE HCL
The objective of the present investigation was to formulate and evaluate the mucoadhesive Venlafaxine HCl microspheres using Hydroxy propyl methyl cellulose K4M as polymer. Venlafaxine HCl is a new generation serotonin r...
EFFECT OF ETHYL ACETATE EXTRACT OF BLACK TEA ON CARDIOVASCULAR COMPLICATIONS ASSOCIATED WITH STREPTOZOTOCIN DIABETIC RATS
Diabetes mellitus (DM) is associated with an increased incidence of cardiovascular events and microvascular complications. These complications contribute to the morbidity and mortality associated with the disease. There...
A REVIEW ON ETHNOMEDICAL USES OF OCIMUM SANCTUM (TULSI)
Traditional remedies are an integral part of Indian culture. Here we present the result of study of ethnomedicine consist study of ancient medical practice which is native or indigenous to a place. It includes etiology o...
EFFICACY OF SOLANUM TORVUM (BERRIES) ON CARRAGEENAN INDUCED RAT PAW EDEMA MODEL AN IN-VIVO ANTI-INFLAMMATORY STUDY
Solanum torvum, commonly called as Hativekuri, is very popular as an anti-inflammatory medicine among the Tiwa communities of Morigaon district Assam, India. The methanolic extract of the raw berries of Solanum torvum wa...
PROTECTIVE EFFECT OF ROOT EXTRACT OF NOTHOSAERVA BRACHIATA WIGHT IN ETHYLENE GLYCOL INDUCED UROLITHIATIC RATS
In India, Berginia ligulata, Family Saxifragaceae is accepted source of ayurvedic drug Pashanabheda. Another species belong to Pashanabheda class is Nothosaerva brachiata Wight. The effect of oral administration of aqueo...