Formulation and Evaluation of sustained release matrix tablets of Glipizide
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2013, Vol 1, Issue 4
Abstract
The aim of present investigation was to enhance the solubility of glipizide (BCS Class II). Glipizide is an oral antidiabetic agent with relatively short elimination half life. Inclusion complex of Glipizide with -cyclodextrin was prepared by kneading method and evaluated for its in-vitro release. Phase solubility studies were performed according to method reported by Higuchi and Connors which was classified as AL type characterized by apparent 1:1 stability constant. The Glipizide & Beta Cyclodextrin found to be compatible which was observed from FTIR spectra of Glipizide - CD Complex. The dissolution study of Glipizide - CD complex shows significant increase in the drug release than pure drug. Matrix Glipizide - CD complex tablet complex equivalent to 10 mg Glipizide were prepared by using Hydroxy propyl methyl cellulose (HPMC), Carboxy methyl cellulose sodium (NaCMC) and Microcrytalline cellulose (MCC). The tablets were evaluated for various tests like hardness, friability, disintegration and in-vitro dissolution studies.
Authors and Affiliations
Shallu Sandhan| Doon Valley Institute of Pharmacy and Medicine, Karnal (Haryana) India, Kavita Sapra| Doon Valley Institute of Pharmacy and Medicine, Karnal (Haryana) India, Jitender Mor| Doon Valley Institute of Pharmacy and Medicine, Karnal (Haryana) India
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