Formulation and Evaluation of Swellable Matrix Tablet Using Emerging Excipient Hibiscus Esculentus
Journal Title: International Journal of Research and Review - Year 2018, Vol 5, Issue 8
Abstract
The present study was undertaken with an objective to expound the swelling ability of Hibiscus esculentus Linn (HEP) powder and its capability to sustain the release of drug. The Okra mucilage was prepared using water extraction method. The physio chemical properties of Okra powder were studied. Ibuprofen was selected as a model drug to observe the sustain character of Okra. FTIR of Okra shows that it has same IR spectra like other polymer such as HPMC. Swellable matrix tablet was prepared by direct compression method using Ibuprofen, Okra Power, HPMC, lactose, magnesium sterate, talc. Combination of Okra and HPMC in the ratio of 25:25 was used in formulation F4 and it was found to be the best one .The formulations were optimized on the basis of acceptable weight variation, thickness, hardness, % friability, % drug content and in vitro drug release. The in vitro release studies were performed using USP type II apparatus using 7.2 pH phosphate buffers as dissolution medium, showed that optimized formulation F4 was found to sustain the release of Ibuprofen over a period of 12 hr.
Authors and Affiliations
Smitharaj R S
Keywords
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