Formulation and Evaluation of Taste Masked Orodispersible Tablets of Ondansetron Hydrochloride
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 4
Abstract
The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. The purpose of this research was to mask the intensely bitter taste of ondansetron HCl and to formulate a orodispersible of the taste-masked drug. Taste masking was done by complexing ondansetron HCl with indion204 in different ratios by the solvent evaporation. Drug- resin complex were optimized by considering parameters such as optimization of resin concentration, optimization of swelling time, optimization of stirring time, optimization of pH and optimization of temperature on maximum drug loading. The effects of variables were observed on maximum amount of the drug loading. During preparation of drug resin complex (resinate), the other variables were kept constant. The resinate was evaluated for taste masking, characterized by X-Ray diffraction and infra red spectrometer. In vitro drug release study of taste masked tablet showed that more than 90 % of the drug release within 20 minutes. Thus, results conclusively demonstrated successful masking of taste and rapid disintegration of the formulated tablets in the oral cavity.
Authors and Affiliations
Sunil H. Makwan , Dr. L. D. Patel , Tejas B. Patel , Timir B Patel , Tushar R. Patel
Keywords
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