Formulation and evaluation of tramadol, and diclofenac sofium multimodel tablet dosage form: an overview
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 9
Abstract
The current article has been focused on the unimodal pain management which are based on either central analgesic drug mechanism or non steroidal anti-inflammatory drug. These drugs control the pain by central nervous system or peripheral nervous system.But in body both system involve for the pain so for moderate to severe pain unimodal approach is not sufficient to address multimodal mechanism of the pain. In the analgesic drug combination when we add peripheral anti-inflammatory drug then this multimodal drug combination provide pure pain relief. The ascending and descending modulation pain pathway message is inhibited by the opioid analgesics and at the site of injury where peripheral nocicepter and peripheral nerve present there NSAID require to relive the pain.
Authors and Affiliations
Rajesh Asija*| Maharishi Arvind Institute of Pharmacy, Jaipur-302020, Rajasthan, India, Shalendra Bhatt| Maharishi Arvind Institute of Pharmacy, Jaipur-302020, Rajasthan, India, Sampat Lal Sharma| Maharishi Arvind Institute of Pharmacy, Jaipur-302020, Rajasthan, India, Prem Chand Dhaker| Maharishi Arvind Institute of Pharmacy, Jaipur-302020, Rajasthan, India
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