FORMULATION AND EVALUATION OF TRANSDERMAL GEL OF KETOROLAC TROMETHAMINE ALONG WITH NEEM OIL, TULSI OIL AND OLEIC ACID AS PENETRATION ENHANCERS
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 1
Abstract
The authors developed and evaluated a transdermal gel formulation of ketorolac tromethamine for the treatment of nociceptive somatic pain. The formulation was optimized for skin permeation enhancers, pH of the system, and dosage strength using in vitro techniques. Ketorolac tromethamine is a non-steroidal anti-inflammatory drug that belongs to class of heteroacetyl derivatives. In present study ketorolac tromethamine topical gel was formulated using Carbopol 940 and Carbopol Ultrez 10NF polymers and three penetration enhancers neem oil, tulsi oil and oleic acid were studied to see the permeation enhancement. Oleic acid was found to be the best penetration enhancer and the three different concentration of oleic acid were used 2%, 3% and 4% w/w to find the best concentration of oleic acid and the best concentration of oleic acid was found to be 3% w/w. Formulations were evaluated for drug content, pH, viscosity, spreadability and release. In vitro release studies were performed using Keshary-Chien diffusion cell. Release kinetic analysis were done to find the kinetics of drug release.
Authors and Affiliations
Dr. G. D. Gupta| Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, Prabhjot Singh Bajwa*| Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India, Aman Sharma| Dept. of Pharmaceutical science, Guru Jambheshwar University of Science & Technology, Hisar
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