Formulation and evaluation of transdermal patch containing amphotericin B

Abstract

Transdermal drug delivery system are topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate. These devices allow for pharmaceuticals to be delivered accross the skin barrier. The human skin is a readily accessible surface for drug delivery. It is an alternative to oral delivery and hypodermic injection. In addition, transdermal system are non-invasive and can be self administered. Amphotericin B is effective against serious or life-threatening systemic fungal infection but not to treat less serious fungal infection of mouth,throat or vagina. It is insoluble in water and having high permeability through stomach. This results in poor bioavailability after oral administration. Therefore transdermal patch containing Amphotericin B was formulated to increase its solubility, bioavailability and patient compliance. solvent casting method was used to formulate transdermal patch. PEG was selected as the permeation enhancer and Glycerin was selected as plasticizer for the formulation and mixed with different concentration of polymeric casting solution which contains HPMC (polymer at different ratios) and Chloroform:Methanol at 1:1 ratio used as solvent. Formulated transdermal patch were then evaluated for drug content, weight variation, flatness, folding endurance, % moisture content, tensile strength, and physical appearance. The in vitro drug diffusion studies revealed that transdermal patch formulation that is F1 shows better drug release profile (97.87%) when compared with other formulations.

Authors and Affiliations

B. Thejeswi , Subhashis Debnath , M Niranjan Babu

Keywords

Related Articles

Drug Designing and Docking studies on PCOS and Hypothyroidism using advanced Cheminformatics tools and database

PCOs and hypothyroidism have many symptoms in common, such as “anovulation” i.e. menstruation without releasing an oocyte (egg cell). Some propose this is the cause of PCOs if anovulation is long term with its related lo...

Analysis of Photochemical and Anti inflammatory activity of selected medicinal plants in rats

To identify the effectiveness of Adhatoda vasica, Garcinia mangostana and Sesbania sesban on anti-inflammatory activity by following histamine-induced paw edema, carrageen an induced paw edema in mice, yeast induced pyre...

Identification of De Novo drug candidate for skin cancer using cheminformatics method

Since 2010, skin cancers result in 80,000 deaths a year, 49,000 of which are due to melanoma and 31,000 of which are due to non-melanoma skin cancers. In this paper, we focus on MCR1 protein which acts as a potential tar...

Gene Expression and Phylogenetic Studies on Genes which is Responsible for Polycystic Ovaries Syndrome

Polycystic ovarian syndrome (PCOS), also known by the name Stein-Leventhal syndrome, is a hormonal problem that causes women to have a variety of symptoms. It should be noted that most women with the condition have a num...

Drug designing and validation studies on human asthma disease gene NPSR1 using Cheminformatics tools

Asthma is defined by the Global Initiative for Asthma as a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. The chronic inflammation is associated with airway hyper resp...

Download PDF file
  • EP ID EP101875
  • DOI -
  • Views 103
  • Downloads 0

How To Cite

B. Thejeswi, Subhashis Debnath, M Niranjan Babu (2015). Formulation and evaluation of transdermal patch containing amphotericin B. International Journal of Novel Trends in Pharmaceutical Sciences, 5(4), 123-129. https://europub.co.uk/articles/-A-101875