FORMULATION AND EVALUATION OF ZIDOVUDINE CONTROLLED RELEASE GAS POWERED SYSTEM USING HYDROPHILLIC POLYMER
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Zidovudine is the first approved compound for the treatment of AIDS; however the main limitation to therapeutic effectiveness of zidovudine is its dose-dependent toxicity, short biological half-life and poor bioavailability. The present research work an attempt has been made to develop the Zidovudine gas powered drug delivery system for controlled release. The Zidovudine gas powered tablets were prepared by direct compression method by using the different grades of hydrophilic polymer like HPMC. The sodium bicarbonates and citric acid were also used as a gas generating agent. The power blend was subjected for pre-compressional parameters. The prepared gas powered tablets are evaluated to post-compressional analysis of parameter such as hardness, friability, weight variation , thickness, drug content, lag time subsequently buoyancy time and in-vitro dissolution studies and swelling index. All the pre and post-compressional parameter are evaluated the results were within acceptable limits. The results of in-vitro buoyancy time and lag time study, the values of in-vitro buoyancy time ranges from 38 to 960 min where as floating lag time ranges from 3.5 to 60 min. The formulation F4 shows the lag time 3.5 min and buoyancy time 960 min. The results of in-vitro buoyancy time and lag time study revealed that as the concentration of sodium bicarbonate increases there is increase in total buoyancy time and decrease in lag time. It is evident from the in-vitro dissolution data that increase in citric acid concentration increased the release rate but reduced the floating time, probably due to of excess carbon dioxide, disturbing the monolithic tablet. The citric acid level in the formulations greatly influenced the drug release. The formulation, F-4 shows maximum drug release at the end of 12 hrs. Form this study, it is concluded that, the formulation retained for longer periods of time in the stomach and provides controlled release of the drug. Hence it may be increase the therapeutic efficacy of the drug by increasing the bioavailability and patient compliance.
Authors and Affiliations
N. G. Rao, M. Shrishail
Keywords
Related Articles
- EP ID EP129880
- DOI -
- Views 137
- Downloads 0
ANTIOXIDANT, CYTOTOXIC PROPERTIES AND PHYTOCHEMICAL SCREENING OF TWO LEBANESE MEDICINAL PLANTS
Nowadays herbal medicine presents a significant adjuvant tool for hard treatment, especially in the case of cancer where modern medicine has access to traditional medicine to deprive the patient of the side effects of th...
SECOND DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF RIFAMPICIN AND PIPERINE IN THEIR COMBINED DOSAGE FORM
The present manuscript describe simple, sensitive, rapid, accurate, precise and cost effective Second derivative spectrophotometric zero crossing point method for the simultaneous determination of Rifampicin and Piperine...
BIOREMEDIATION OF PICOLINE BY ADAPTING P. AERUGINOSA ISOLATED FROM INDUSTRIAL EFFLUENT POLLUTED WATER
Environmental pollution implies any alteration in the surroundings but it is restricted in use especially to mean any deterioration in the physical, chemical, and biological quality of the environment. All types of pollu...
A NOVEL TRANSDERMAL DRUG DELIVERY SYSTEM
Trasdermal drug delivery system is topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate. Today about 74% of drugs are taken orally and a...
A PROSPECTIVE STUDY OF ANTITUBERCULOSIS DRUG-INDUCEDHEPATOTOXICITY AND ITS MANAGEMENT IN A TERTIARY CARE HOSPITAL
Tuberculosis (TB) is a very common form of droplet infection. If untreated, the disease may be fatal within 5 years in more than half of cases. To study the frequency of anti-tuberculosis therapy (ATT) induced hepatotoxi...