Formulation and in Vitro Characterisation of Self Emulsifying Drug Delivery System of Diclofenac for the Enhancement of Dissolution and Solubility
Journal Title: International Journal for Research in Applied Science and Engineering Technology (IJRASET) - Year 2017, Vol 5, Issue 2
Abstract
Diclofenac , non-steroidal anti-inflammatory drug (NSAID) belongs to BCS Class II drug with low dissolution and poor aqueous solubility. The main aim of the present study was to improve the solubility and dissolution rate of diclofenac using self-emulsifying drug delivery technique. Micro emulsion region was formed by preparing the ternary phase diagram. Ratio 0.15:0.85 , 0.5:0.5 and 0.3:0.7 was selected as the self-emulsification region for the development of formulation . Drug – excipient studies were performed by FT-IR .Parameters were evaluated include time of emulsification , freezing and thawing and dissolution. The present research work describes SEDDS of Diclofenac using olive oil, Tween 20 and PEG200 prepared by simple vortex in the mixture at 40 °c and packed in hard gelatine capsule shell of 00 size. In vitro dissolution was carried out using USPII by 6.8 pH buffer at 75 RPM and samples were measured at 276 nm using UV-Visible spectroscopy. From the studies the optimized SEDDS was composed of 30% oil, 45% Surfactant and 25% Co surfactant. The optimized formulation was found to be showing significant improvement in drug release and had 24 seconds self-emulsification time , having drug content 101.16% and complete 99.01% drug release in 60 minutes.
Authors and Affiliations
K. A. Chowdary, V. Phanendra Babu, Srinivasa Rao. B
Keywords
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- EP ID EP23189
- DOI http://doi.org/10.22214/ijraset.2017.2101
- Views 239
- Downloads 7
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