FORMULATION AND IN-VITRO CHARACTERISATION OF VILAZODONE IMMEDIATE RELEASE TABLETS
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 6
Abstract
The aim of the present study is to develop and evaluate the immediate release tablet of Vilazodone by direct compression method. The superdisintegrant crospovidone (CP), croscarmellose sodium (CCS), sodium starch glycolate (SSG), and Locust beam gum were used for the immediate release of drug from the tablet. Optimization of superdisintegrant concentration that can control the release of the drug as the hypothetical release profile was based on the release profile of the prepared trials. The prepared tablets were evaluated for all pre-compression parameters. Evaluation parameters Like weight variation, the hardness of the tablet, friability, thickness, disintegration test, drug content uniformity, and in-vitro release studies were performed. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. Among all the formulations, a formulation containing croscarmellose sodium as a super disintegrant is fulfilling all the parameters satisfactorily. The study reveals that formulations prepared by direct compression F5 exhibits the highest dissolution using croscarmellose sodium showed faster drug release 96.57% over 30 min.
Authors and Affiliations
P. Suresh Kumar et al.
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