Formulation and In Vitro Evaluation of Chitosan and Hydroxy Ethyl Cellulose Interpenetrating Polymer Networks for Diltiazem Hydrochloride
Journal Title: Scholars Bulletin - Year 2015, Vol 1, Issue 5
Abstract
Abstract: The purpose of this study was to develop a Interpenetrating Polymer Network (IPN) of Chitosan and Hydroxy Ethyl Cellulose (HEC). The drug Diltiazem HCl, used in the treatment of angina pectoris, hypertension and cardiac arrhythmia. Diltiazem HCl has a short elimination half-life; this will bring down its dosing frequency to once a day and on the same time make a zero order release system. Microspheres were prepared by using controlled release polymers. The formulations were evaluated for pharmacopoeial quality control tests and all the physical parameters evaluated were within the acceptable limits. Formulation B7 was proved to be good drug content, % drug encapsulation efficiency and % drug release up to 12 h as compared to the other formulations. Stability studies were carried out on the optimized formulation B7 for period of 3 months at 400c/75%RH. Finally it was observed that there was no change in physiochemical and physical properties as well as in drug release profile even after storage at 45°C and 75 % RH for three months. Keywords: Interpenetration polymer networks, Diltiazem hydrochloride, drug encapsulation efficiency, stability study
Authors and Affiliations
Sirajudheen MK, Chordiya MA, Naseef PP, Senthilkumaran K
Keywords
Related Articles
- EP ID EP378089
- DOI -
- Views 166
- Downloads 0
Quality of Life Issues on Pangkor Island, Malaysia
Abstract: The total population of Pangkor Island in 2013 is about 17,162 and is made up of two major groups, Chinese residents (48.46%) followed by Malay residents (41.98%). The main economic activities of the residents...
Evaluation on Dalong Formation Hydrocarbon Source Rock in the Northwest Sichuan Province
Abstract:The best source rocks, is a prerequisite for further oil and gas exploration in the sedimentary basin, hydrocarbon source rock evaluation of oil and gas migration, accumulation, basic research. The Permian reser...
Organizational Culture and Innovation in Selected Breweries in South-East Nigeria
Abstract:The brewing industry in Nigeria appears characterised by a lot of rivalry in its struggle for dominance. In a bid to gain and retain their market share, the firms have adopted product innovation as a strategy. U...
Children Literature Education in Nigeria and the Challenges of Readership
Abstract: Children, the leaders of tomorrow, are usually the hope and aspiration of every society. Hence, the literature which enhances the education especially the writing and readership skills of children need to be ex...
Characterization of Channel Sand Based on Forward Modeling and Waveform Clustering
Abstract:For the specific issues, this paper, based on all kinds of seismic attributes, using the technology of the forward modeling, analysis the sensitive attributes of various types of sand body development model, sel...