Formulation and In Vitro Evaluation of Ciprofloxacin Matrix Tablets: Effect of DrugPolymer Ratio
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 5
Abstract
Received 25 April 2018 Revised 08 May 2018 Accepted 09 May 2018 Published online 10 May 2018 An ideal tablet should combine good mechanical strength with adequate drug release profile. This work aims to study the effect of drug-polymer ratio on the mechanical properties and release profile of ciprofloxacin tablet. Ciprofloxacin formulations containing drug and the polymers (Chrysophyllum albidum gum (CAG), hydroxypropylmethylcellulose (HPMC) and xanthan gum) in ratios of 2:1, 1:1 and 1:2, respectively were prepared by direct compression. The crushing strength, friability and the time taken for 50% (T50) and 90% (T90) drug release were obtained. The mechanism of drug release was also determined. Tablets containing CAG had significantly (p<0.05) lower crushing strength than those containing other polymers. In tablets containing xanthan gum and HPMC, there was an increase in crushing strength as the amount of polymer was increased to equal amount with the drug, but a further increase in polymer concentration to twice the amount of the drug resulted in a decrease in strength. T50 and T90 increased with increase in polymer concentration for formulations containing CAG. Drug release in formulations containing CAG and xanthan gum was by first order kinetics while the zero order model was the most prominent in tablets with HPMC. The first order constant, k1 decreased with increase in polymer concentration for tablets with CAG while the reverse was the case for xanthan gum. However, irrespective of the drug-polymer ratio, all the formulations exhibited super case transport mechanism. This study suggests that the drug-polymer ratio has a significant influence on the mechanical strength and the release profile of ciprofloxacin tablets
Authors and Affiliations
Lateef G. Bakre, Temitayo O. Sholuade
Keywords
Related Articles
- EP ID EP490539
- DOI 10.26538/tjnpr/v2i5.9
- Views 94
- Downloads 0
The Role of Metallothionein and Some Micronutrients in the Pathogenesis of HIV Infection: A Review
Received 12 June 2018 Revised 25 June 2018 Accepted 27 June 2018 Published online 08 July 2018 Human immunodeficiency virus (HIV) infection remains a major public health challenge especially in sub-Sahara Africa where t...
Assessment of Stroke Awareness Among Public Servants in a Study Population in Nigeria
Received 11 May 2018 Revised 27 May 2018 Accepted 31 May 2018 Published online 07 June 2018 This study aimed at assessing the degree of awareness of stroke among the public servants in Benin City, Edo State. Specific ob...
Effect of Ethanol Extract of Phyllantus niruri Leaf on Carbon Tetrachloride Induced Hepatotoxicity and Oxidative Stress in Rats
Received 04 June 2018 Revised 05 July 2018 Accepted 06 July 2018 Published online 08 July 2018 The hepatoprotective effect of the ethanol extract of Phyllanthus niruri in carbon tetrachlorideinduced hepatotoxicity in ra...
Anti-seizure activity of Extract of Jatropha gossypiifolia Linn (Euphorbiaceae)
Received 13 January 2018 Revised 27 January 2018 Accepted 02 February 2018 Published online 07 February 2018 The leaves of Jatropha gossypiifolia has been widely used for the treatment of epilepsy and childhood convuls...
Coconut (Cocos nucifera) and Moringa (Moringa oleifera) Oils Protect Against Cadmium-induced Toxicity in Albino Rats
Received 20 February 2018 Revised 26 March 2018 Accepted 02 April 2018 Published online 07 April 2018 Exposure to heavy metals is currently an increasing source of concern worldwide. The present study evaluated the effe...