FORMULATION AND IN-VITRO EVALUATION OF CLARITHROMYCIN PERIODONTAL STRIPS FOR PERIODONTITIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
Periodontitis is an inflammatory response to the overgrowth of anaerobic organisms in the sub gingiva and if unchecked, results in the destruction of the bone and soft tissues supporting the tooth. Studies suggest that clarithromycin can attain higher concentration in the inflammed gingiva and it also produces anti-inflammatory effect. The systemic drug administration has been useful in treating periodontitis but the disadvantage that, the drug is diluted several thousand folds before it reaches the site. This problem can be overcome by administering the drug directly to the intended site of action with lesser dose. In present study periodontal strips were prepared by using solvent casting technique. Formulations were designed by taking Ethyl cellulose alone and with copolymers (HPMC K4M, Eudragit RS‐ 100, PVP K30) was dissolved in chloroform and dichloromethane (1:1) solution, using dibutyl phthalate and PEG‐400 as plasticizers.
Authors and Affiliations
Sudeep Kothari , G Gnanaranjan , Preeti Kothiyal
Keywords
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