Formulation and In-Vitro Evaluation of Elvitegravir Fast Disintegrating Tablets
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 1
Abstract
Abstract: Elvitegravir is an antiretroviral drug which belongs to BCS class-II of Biopharmaceutics classification. In the present work an attempt has been made to prepare solid dispersion of elvitegravir by using polyethylene glycol (PEG) and then compressing it along with suitable excipients to develop fast disintegrating tablets. Preparation of solid dispersions and then fast disintegrating tablets improves its solubility and then the absorption of drug. The solid dispersion (drug: PEG 6000, 1:3 ratio) used to prepare fast disintegrating tablet by direct compression method using superdisintegrants such as sodium starch glycolate, cross caramellose sodium and crospovidone. The precompression parameter of powder blends suggested good flowability and compressibility. The prepared tablets were evaluated for thickness, hardness, friability, weight variation, drug content, wetting time, water absorption ratio, in-vitro disintegration time and dissolution studies. Among the various formulations tablets the batch F-6 prepared with 20 mg Crospovidone showed complete release of drug within 15 minutes. Hence fast dissolving tablets of elvitegravir by solid dispersion technique could be used to improve patient compliance.
Authors and Affiliations
K. Navaneetha, N. Jabili, B. Venkateswara Reddy, T. Saritha
Keywords
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