FORMULATION AND IN VITRO EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF LEVOSULPIRIDE BY USING NATURAL POLYMERS
Journal Title: International Journal of Drug Regulatory Affairs - Year 2017, Vol 5, Issue 2
Abstract
The aim of the present study was to develop sustained release formulation of Levosulpiride to maintain constant therapeutic levels of the drug for over 12 hrs. By using various Natural polymers like Fenugreek, Almond gum and Tamarind gum were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F8) showed better and desired drug release pattern i.e., 99.81% in 12hours. It contains the Fenugreek 1:1.5 ratio as sustained release material. It followed zero order kinetics.
Authors and Affiliations
Vageesh N. M, Ramya Sri Sura, Swathi B, K Gulijar Begum
Keywords
Related Articles
- EP ID EP326726
- DOI 10.22270/ijdra.v5i2.200
- Views 162
- Downloads 0
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