FORMULATION AND IN VITRO EVALUATION OF GASTRO RETENTIVE SUPERPOROUS HYDROGEL TABLETS OF SUMATRIPTAN
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
Superporous hydrogels (SPHs) are porous hydrophilic cross-linked structures with the facility of absorbing aqueous fluids. Initially hydrogels were developed as a novel drug delivery system for gastric retention devices. But they have the disadvantage that, they swells into aqueous fluids at slow rate (it takes several hours to attain equilibrium swelling), but many of the pharmaceutical applications need fast swelling property. Therefore Superporous hydrogels were developed, these systems have to immediately swell in the stomach and retain their consistency in the insensible stomach environment, while releasing the pharmaceutical active constituent. In the present study Superporous Hydrogel tablets of Sumatriptan were prepared by direct compression method. The directly compressed formulations exhibited better in-vitro drug release profiles. The formulation F10 prepared by direct compression containing chitosan, formaldehyde, sodium bicarbonate prepared by cross-linking technique exhibited good swelling index and maximum rate of drug release. Thus the formulated Superporous Hydrogel tablets of Sumatriptan offer a superior alternative over conventional marketed dosage forms in regards of controlled release of drug. FTIR studies combined with stability studies proved the integrity of the developed tablets.Therefore the prepared tablet shows improved bioavailability with increased drug release.
Authors and Affiliations
Ramavath Naresh Naik , B. Arun kumar1
Keywords
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