FORMULATION AND IN-VITRO EVALUATION OF HOLLOW MICROSPHERES OF GLIPIZIDE

Journal Title: International Journal of Drug Regulatory Affairs - Year 2017, Vol 5, Issue 4

Abstract

Present work involves attempts to improve floating time of glipizide by formulation of hollow microspheres incorporating Glyceryl Monostearate and acryflow. The floating microspheres were evaluated for percentage yield, drug loading, In-vitro buoyancy behavior as well as in-vitro drug release. The micrometric properties were found to be good and scanning electron microscopy shows that the microspheres were spherical with smooth surface and a hallow cavity inside microspheres. The practical yield was found to be in the range of 83.88-90.98% and with a particle size range of 320-480 µm. The percent entrapment is about 76 % to 91 % which decreased with increase in HPMC concentration in the formulations. The microspheres with high concentrations of Acrycoat S100 showed higher buoyancy. The in-vitro release was slow and extended to more than 12 hours which increased with significant increase in HPMC concentration but decreased in buoyancy character. Release obeys zero order kinetics and the drug release was diffusion controlled. Hence it can be concluded that the floating microsphere of Glipizide may prolong drug release thereby improving bioavailability and enhance opportunity of absorption in stomach.

Authors and Affiliations

Arun Kumar, Anil Midda, Mahesh Jhanjharia

Keywords

Related Articles

REGULATORY TECHNICALITIES FOR DRUG PRODUCT REGISTRATION IN BRAZIL

Brazilians are demanding better healthcare and modern medicines, presenting significant opportunities for foreign investment. In Brazil, medicinal product registration is an extensive process. To do business in Brazil is...

Regulation of Blood and Blood products in India, USA and EU

Blood and blood products are precious commodity which gives life to another person. Though we have immense discoveries and invention in science and technology, yet we cannot make blood hence, human blood has no substitut...

STEVIA AN UNTOUCHED NATURE’S GIFT CAN BE A BOON TO DIABETIC

Plants and fungi are a vital part of healthcare. Over 80% of the global population rely on traditional medicine, much of which is based on plant remedies. Traditional Chinese medicine alone uses over 5,000 plant species....

FORMULATION AND DEVELOPMENT OF KETOPROFEN BILAYER TABLETS

Aim of present research work was formulation and development of bilayer tablets of Ketoprofen to reduce the side effects of Ketoprofen and to improve the therapeutic benefits and patients’ compliance to treatment. Bi-lay...

OCULAR DRUG DELIVERY: RECENT UPDATES

Ophthalmic route is one of the most promising delivery systems for the treatment of eye ailments. Delivery of medicaments to anterior segment of the eye is an easy task. However with the rising number of posterior segmen...

Download PDF file
  • EP ID EP329146
  • DOI 10.22270/ijdra.v5i4.211
  • Views 100
  • Downloads 0

How To Cite

Arun Kumar, Anil Midda, Mahesh Jhanjharia (2017). FORMULATION AND IN-VITRO EVALUATION OF HOLLOW MICROSPHERES OF GLIPIZIDE. International Journal of Drug Regulatory Affairs, 5(4), 68-74. https://europub.co.uk/articles/-A-329146