Formulation and In-Vitro Evaluation of Polymers Blend Based Diclofenac Sodium Microparticles for Sustained Release Drug Delivery
Journal Title: RADS Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Purpose: The purpose of research was to formulate polymeric blend based Diclofenac sodium microparticles for sustained release drug delivery. Method: The diclofenac sodium microparticles were formulated by emulsification and solvent evaporation method. The diclofenac loaded microparticles were evaluated or characterized for different parameters such as, micrometric properties, particle size, particle shape measurement, encapsulation and loading efficiency, FTIR, dissolution and drug release kinetics studies. Results: Compact white spherical shaped microparticles of Diclofenac sodium microparticles were observed under optical microscope with a size of 169 - 552 µm. All formulation showed good percentage yield (96-100%). There was no effect of either increased or decreased concentration of polymers observed. Concentration of polymers and sustained release behavior of drug was directly proportional. In-vitro drug release study was performed in 0.2M HCl (pH 1.2) for first 2 hours, then followed by 0.2 M phosphate buffer solution (pH 6.8) for next 6 hours. The drug release from microparticles was irregular diffusion process. Conclusion: From the study, it was evident that a suitable combination of polymers is necessary to achieve desired effects. Diclofenac Sodium microparticles can be used to reduce adverse effects and increase the patient compliance.
Authors and Affiliations
Mukarram Anees
Keywords
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