FORMULATION AND IN-VITRO EVALUATION OF TERBUTALINE SULPHATE SUSTAINED RELEASE TABLETS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
Sustain release formulation maintain a constant level plasma concentration of drug so that multiple and night dosing can be avoided. Terbutaline sulphate is a β2 stimulant drug which is having a very short half life of less than 4 hours. It is available in conventional dosage form in thrice a day formulation. Being half life less there is always a need for dosing frequency. Decreasing dosing frequency will increase the patient compliance for asthmatic patients and thus avoiding dosing at odd hours. Terbutaline sulphate is available in market in different immediate release dosage forms. After some time plasma concentration level decreases below MEC. So the necessity of producing the drug in sustained release formulation. So an attempt is made to formulate terbutaline sulphate in sustained release formulation with different concentrations of HPMC K15 and HPMC K4M polymers so that it can provide effective drug release up to 12 hours. The powder blend is subjected to pre compressional parameters. The prepared tablets were subjected to post compressional parameters. The results of the present study showed that the polymer ratio used in the formulation F5 showed enhanced result and released the drug up to 12 hours with 99 % drug release.
Authors and Affiliations
Rajeswari Kola, Deepa Ramani N, Pragati Kumar B
Keywords
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