FORMULATION AND IN -VITRO EVALUATION OF ZOLMITRIPTAN MUCOADHESIVE BUCCAL PATCHES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
The present work has been done for the preparation of mucoadhesive buccal pathes of zolmitriptan by solvent casting method with the use of different polymers like HPMC K4M, HPC, Na CMC, PVP. The prepared patches were evaluated for uniform thickness, folding endurance, swelling index, surface pH, drug content uniformity, in vitro residence time, drug release study and Ex-vivomucoadhesion strength. Among all the formulations F2 was selected as optimum formulation. F2 containing HPMC and HPC has folding endurance (302.21±1.078), surface pH(6.812±0.002), mucoadhesion strength(21.023±0.055 g) and resistence time(6.2±0.25 hrs). The IR spectra studies disclosed that there is no interaction between drug and polymer.
Authors and Affiliations
Prasanna Abbaraju , Rajini Giddam , Ajay Kumar.
Keywords
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