FORMULATION AND OPTIMIZATION OF FAST DISSOLVING TABLETS OF PROMETHAZINE THEOCLATE USING 32 FACTORIAL DESIGN
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
The fast dissolving tablets of Promethazine Theoclate were prepared by sublimation technique, using 32 full factorial design. This research work aimed to study and to develop a unique drug delivery system for immediate release of drugs which can dissolve readily when placed in the oral cavity. The different subliming agents (Camphor, Urea and Menthol) in varying concentration (5-15% w/w) were used to develop the tablets. Total 12 formulations were prepared and evaluated for pre-compression and post compression characteristics. The optimization of the batches was carried out using 32 full factorial design and results of polynomial equation were analyzed using ANOVA and regression analysis. By the use of desirability approach final optimized formulation was prepared.
Authors and Affiliations
Shiv Hardenia
Keywords
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