Formulation and Pharmacological Evaluation of Bark Extract of Albizia Odoratissima (L.F) Benth
Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 1
Abstract
Albizia Odoratissima has been used in folk medicines for the treatment of Diabetes. To substantiate this claim the present studies have been undertaken in order to evaluate the Antihyperglycemic activity of Alcoholic extract of bark of Albizia odoratissima (AlEAO) and its Aqueous extract of bark of Albizia Odoratissima (AqEAO). These two fractions was assessed for hypoglycaemic activity on alloxan induced (150mg/kg) swiss albino rats. The LD50 of the extracts were found to be 1000mg/kg.The extract powder are formulated as conventional dosage form by direct compression technique using polymer HPMC K4M and CMC Sodium in the concentration range of 5%. The tablets are evaluated with alloxan induced diabetic rats. The antidiabetic activity was compared with that of the reference drug glibenclamide (5mg/kg). The AlEAO fraction produces the significant reduction (P˂0.001) in BGL (Blood Glucose Level) after singe administration (Dose: 100mg/kg, Route: Oral) for 10 days prolonged treatment. The BGL was measured using Glucometer on the 0th, 3rd and 10th day. The AlEAO shows the significant hypoglycaemic activity compared to that of the standard drug.
Authors and Affiliations
Margret Chandira, A. Pasupati, S. Kumar, Debjit Bhowmik, B Jayakar
Keywords
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