Formulation and Pharmacological Evaluation of Bark Extract of Albizia Odoratissima (L.F) Benth
Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 1
Abstract
Albizia Odoratissima has been used in folk medicines for the treatment of Diabetes. To substantiate this claim the present studies have been undertaken in order to evaluate the Antihyperglycemic activity of Alcoholic extract of bark of Albizia odoratissima (AlEAO) and its Aqueous extract of bark of Albizia Odoratissima (AqEAO). These two fractions was assessed for hypoglycaemic activity on alloxan induced (150mg/kg) swiss albino rats. The LD50 of the extracts were found to be 1000mg/kg.The extract powder are formulated as conventional dosage form by direct compression technique using polymer HPMC K4M and CMC Sodium in the concentration range of 5%. The tablets are evaluated with alloxan induced diabetic rats. The antidiabetic activity was compared with that of the reference drug glibenclamide (5mg/kg). The AlEAO fraction produces the significant reduction (P˂0.001) in BGL (Blood Glucose Level) after singe administration (Dose: 100mg/kg, Route: Oral) for 10 days prolonged treatment. The BGL was measured using Glucometer on the 0th, 3rd and 10th day. The AlEAO shows the significant hypoglycaemic activity compared to that of the standard drug.
Authors and Affiliations
Margret Chandira, A. Pasupati, S. Kumar, Debjit Bhowmik, B Jayakar
Keywords
Related Articles
- EP ID EP156008
- DOI -
- Views 109
- Downloads 0
Antibiotic Prescription and Cost Patterns In An Intensive Care Unit: A Review of Literature
Patients admitted to the ICU are seriously ill and often suffer from chronic critical illnesses. Antibiotics are the most frequently prescribed drugs among hospitalized patients especially in intensive care and surgical...
Colon targeted drug delivery systems – A Potential Approach
Day by day there are new developments in field of colon specific drug delivery system. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases asso...
Cleaning Validation of Albendazole Tablets 400 mg
The cleaning validation is to verify the effectiveness of the cleaning procedure for removal of product residues, degradation products, preservatives, excipients and cleaning agents so that the analytical monitoring may...
Chronopharmacology: As A Therapy for Cardiovascular Disease
Chronopharmacology is the study of the manner & extent to which the kinetics & dynamics of medication directly affected by endogenous biological rhythm & also how the dosing time of medications affects biolog...
Inventory Management: A Tool of Identifying Items That Need Greater Attention for Control
Cost analysis plays a pivotal role in the management of pharmacy store. About one-third of the hospital budget is spent on purchasing materials and supplies including medicines. The pharmacy is one of the most extensivel...