Formulation and stability study of lipid-based formulations for oral administration of poorly water-soluble drug
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 2
Abstract
Rousuvastatin calcium (ROS) is a model of poorly water-soluble drug. The objective of the study was to increase the dissolution rate and stability of ROS through formulation of basic tablets, contain nanoemulsion of the drug. Full factorial design (23) was applied for a screening study in which three factors were used at two levels (low and high). The factors were the type of disintegrants (Ac-di-sol, Explotab), the concentration of disintegrant (3%w/w, 5%w/w) and the binder type (Avicel PH101, PEG6000). The tablets are prepared by direct compression. The weight variation, content uniformity, friability, hardness, disintegration time, and in-vitro dissolution of the prepared formulae were evaluated. The stability of tablets was also studied at 40°C & 75% RH for period of 3 months at 40°C. The tablets were prepared by direct compression technique. The formula F6 containing Ac-di-sol (5%w/w) with AvicelPH101 (30%w/w) has the least disintegration time (45.55 ± 4 seconds) and the highest dissolution rate (95±3.6%). The stability of tablets was studied at 40°C & 75 % RH for period of 3 months. The results indicate that ROS tablets may serve as a successful strategy for enhancing the dissolution and stability.
Authors and Affiliations
Dr. Demiana Monier Naguib
Keywords
Related Articles
- EP ID EP194989
- DOI -
- Views 82
- Downloads 0
Pharmacognostical Studies of Azima Tetracantha Lam. (Salvadoraceae)
The present study deals with evaluation of pharmacognostical characters of an important medicinal plant, Azima tetracantha Lam. The pharmacognostical studies were carried out such as organoleptic, macroscopic, microscopi...
Protective Effect of Cinnamon Aqueous Extract on Cypermethrin-Induced Hepatotoxicity in Albino Rats
Cypermethrin is a synthetic pyrethroid with potent insecticidal property. Cinnamon is one of the oldest medicinal plants used in traditional medicine.The present work was carried out to evaluate the effect of cinnamon aq...
Design, development and evaluation of elixir of gymnema sylvestre by using leaf extract
The aim of this study is to prepare Gymnema sylvestre elixir by using leaf extract. In this study Sodium Saccharin, methyl paraben and propyl paraben was taken as polymer. There are many drugs available to control and tr...
Eco-friendly synthesis and characterization of silver nanoparticles using Vitex leucoxylon linn leaf extract and their study of its antibacterial and anti-fungal activities
Eco-friendly synthesis of stable Silver nanoparticles (AgNPs) was carried out using the aqueous extract of vitex leucoxylon leaves. The UV-Vis spectrum was recorded to monitor the formation of the nanoparticles, which ex...
Comparative study of rheumatoid factor with anti - CCP antibodies by ELISA method in the diagnosis of rheumatoid arthritis
Rheumatoid Arthritis is a chronic inflammatory disease of unknown aetiology marked by a symmetric peripheral polyarthritis. It is the most common form of chronic inflammatory arthritis and often results in joint damage a...