Formulation characterization and in-vitro evaluation of class 1c antiarrhythmic agent: propafenone into transdermal patches
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2018, Vol 10, Issue 1
Abstract
In the present research work PROPAFENONE an anti-arrhythmia agent was selected for the formulation and preparation of transdermal patches as a model drug, using HPMC-15 cps and Methocel K100 as release controlling agents from patches along with sodium alginate are used. Transdermal patches were prepared using HPMC-15cps from trials T-1 to t-5, in which concentrations of HPMC-15 cps used in increasing concentrations. Similarly same in case of trials T6 to T10 was used with Methocel K 100. In-house films were taken for in-vitro evaluation tests and found to be 109 mg to 365 mg. whereas folding endurance test was found to be 56 times for TRIAL-1 and 126 times for TRIAL-10. In case of moisture content test TRIAL -10 showed less percent of moisture with 1.14 and TRIAL-4 Showed 3.54. For water uptake studies patches of TRAIL-10 absorbed 0.98 percent and TRIAL -2 of 1.63 percent. When comes to tensile strength of in-house prepared patches lease of TRIAL-6 with 63 and maximum of TRIAL-10 with 106. Release kinetics was also determined for optimized trial T10 and the drug release was found to be in following order, Zero order-0.995>Koresmeyer Peppas plot-0.972>First order>0.932>Higuchis plot-0.923. Based on the above R2 values it has been concluded that the release of PROPAFENONE was following Zero order rate kinetics with R2 value 0.995.
Authors and Affiliations
Dr. P. Shashidhar, Dr. M. Sunitha, Dr. D. Ramakrishna and Ms. Mariyam Ali -
Keywords
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