FORMULATION, CHARACTERIZATION AND STABILITY STUDY OF AZADIRACHTA INDICA (NEEM) FRUITS EXTRACT
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 1
Abstract
Herbal medicines have long history of use; they are renewable, cheaper source with better patient tolerance as well as acceptance. Wounding of skin is one of the common dermatological problems. Therefore, there is great need for new topical treatment that can speed up healing, minimize scarring and decreases induction of bacterial resistance. Neem trees as known they have an immunomodulatory, anti-oxidant, anti-inflammatory, antimicrobial and wound healing promoting properties. Hence this study aimed to formulate, evaluate and standardize Neem ointment and Neem gel formulae and also to study their stability. The Dried Neem fruits were extracted and then the highest antimicrobial extract was formulated two formulae of polyethylene glycol ointment and carbopol gel with concentration 3% were prepared. All the quality control tests were done for the prepared Neem formulae such as appearance, pH, content uniformity, viscosity, spreadability, washability and antimicrobial activity. Accelerated stability study test was done. Crude Neem extract, ointment and gel were standardized using high performance liquid chromatography method. This study results shows that the Neem ointment and gel quality Control results complied with the requirements stated in the official American pharmacopeia. Also the stability test results indicate stable formulae with no significant change. Furthermore, the high performance liquid chromatography results indicate the presence of major Neem marker compound. The presence of the Neem chemical constituents such as tannins, terpenoids and flavonoids with its positive antioxidant activity results may support the wound healing activity of Neem.
Authors and Affiliations
Dr. Lamia Abdalla Gadien
Keywords
Related Articles
- EP ID EP666889
- DOI -
- Views 136
- Downloads 0
DRUG APPROVAL PROCESS ACROSS THE UNITED STATES, EUROPEAN UNION (ITALY), AND CANADA
This study highlights the Drug approval pathways across the USA (USFDA), Europe (EMA) and Canada (Health Canada). USFDA and Health Canada follow a centralized procedure. Hence, in the US and Canada, clinical trials and m...
CONCEPTUAL STUDY OF SHEETAPITTA WITH SPECIAL REFERENCE TO URTICARIA
Ayurveda is the science of life providing guidelines on ideal daily and seasonal routines, diet, behaviour and proper use of senses for healthy and happy life. It suggests health as the balanced and dynamic integration b...
APPLICATION OF THE METHOD OF THERMAL-SECURITY SURFACE-IONIZATION SPECTROSCOPY IN ANALYSIS OF ALKALOIDS OF CONIUM MACULATUM
Cicuta maculata is a species of flowering plants in the carrot family, known by several common names, including spotted water hemlock, spotted parsley, spotted cowboy and the root of suicide in the Iroquois. In this arti...
REALISTIC INFORMATION SURVEY STUDY ON GENERIC VS BRAND NAME MEDICINES FROM PEOPLES POINT OF VIEW
Now a day we are doing the work for developing the awareness about generic medicines. But nobody wants to keep reality in front of peoples about generics. Also realistic information survey (RISF) study suggests that alth...
THE SUBSTANTION OF THE TABLET MASS “AMBROL” COMPOSITION CHOICE FOR TABLETIZING
Non-narcotic drugs are divided into two main groups. First group includes drugs of central action for instance, butamiratome, glaucine, ledin, pentoxiverin, okseladin and folkodinom; second group includes drugs that have...