FORMULATION DESIGN AND OPTIMIZATION OF ORAL FLOATING MATRIX TABLETS OF CIPROFLOXACIN HCL BY USING HPMC AND XANTHAN GUM WITH EXPERIMENTAL DESIGN
Journal Title: Asian Journal Of Pharmaceutical Research and Development - Year 2018, Vol 6, Issue 6
Abstract
The oral floating matrix tablets of Ciprofloxacin Hydrochloride were formulated by Experimental design by using HPMC K100M and Xanthan gum as the retardant polymers each with three different levels with an approach to increase gastric residence andthereby improve drug bioavailability. From FTIR results confirm the absence of chemical interaction between the drug with the excipients used in tablet formulations. Also, there was no shift in the endotherm of in the drug-excipients mixtures indicating compatibility of drug with all the excipients. All the tablets were prepared by effervescent approach in which Sodium bicarbonate was added as a gas generating agent. Floating Matrix tablets were prepared by direct compression method and prepared tablets were evaluated for weight variation, percentage friability, hardness and drug content studies. All the formulations showed compliance with pharmacopeia standards. Floating lag times of all the formulations were within 1 minute and Total floating time of allthe formulations were more than 12 hours. In vitro release studies revealed that the release rate decreased with increase polymer proportion of retarding polymers. The formulation CHX8sustained release of drug for 12 hrs with 20% release of drug after 1hr and more than 97% at the end of 12 hrs. From the Kinetic model it was found that the optimized formulation CHX8showed linearity in case of Zero order (R2: 0.952) and Higuchi model (R2: 0.948). By fitting data to Korsmeyer-Peppas model and ‘n’ value lying above 0.5 indicating non Fickian release.
Authors and Affiliations
Gourishyam Pasa
Keywords
Related Articles
- EP ID EP516257
- DOI 10.22270/ajprd.v6i6.430
- Views 160
- Downloads 0
SIGNIFICANCE OF DOSHAS IN MANAGEMENT OF VARIOUS DISEASES
In Ayurveda, the span of life is described to be determined on the basis of nature of the physique, type of constitution The utility of Ayurveda is to help maintain the health of a healthy individual a...
A REVIEW ON: WOUND HEALING
Wound healing is a biological process that begins with trauma and ends with scar formation. There are two types of tissue injury: full and partial thickness. Partial thickness injury is limited to the epidermis and super...
PHARMACOGNOSTIC PROFILE AND PHARMACOLOGICAL ACTIVITY OF DIFFERENT PARTS OF AMORPHOPHALLUS CAMPANULATUS (ROXB.) BLUME- A COMPLETE OVERVIEW
Amorphophallus campanulatus (Roxb.) Blume is a valuable corm producing plant in the world. It is most commonly named as Elephant foot yam. Among all species of Amorphophallus, Amorphophallus camp...
CHEMICAL HYDROLYSIS, INSILICOPHYSICOCHEMICAL PROPERTIESANDIN-VIVOPHARMACOLOGICAL EVALUATION OF ANTIDIABTIC AND ANTIHYPERTENSIVE CODRUGS
n the present research work codrugs of Propranolol and Metoprolol with Metformin were synthesized with an aim of improving the biological activity and to check the effectiveness of release of the parent dru...
OXIDATIVE STABILITY OF CANOLA OIL BY PHYSICO-CHEMICAL ANALYSIS AND FT-IR SPECTROSCOPY
This study was conducted to investigate the stability of canola oil after convention heating and repeated frying with potato piece. The progress of lipid oxidation was assessed in terms of phys...