FORMULATION DEVELOPMENT AND EVALUATION OF ALMOND GUM BASED SUSTAINED RELEASE MATRIX TABLET OF INDOMETHACIN
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 12
Abstract
Objective: The aspiration of the current research involves employing various concentrations of polymer and filler to develop indomethacin sustained release (SR) matrix tablets. The objective of this research work is to reduce dosing frequency thereby increasing patients compliance and enhanced therapeutic activity.Methods: Polymers such as Almond gum (AG), polyvinylpyrrolidone (PVP), and starch at different concentrations were used for formulating SR polymeric matrix tablets. Evaluation of pre-compression and post-compression parameters was done for both granules and formulated tablets.Results: Results obtained from pre-compression parameters and post-compression parameters suggested that all the parameters are within the prescribed limits, demonstrating that formulated granules had shown better flow properties. The morphological characteristics of the developed tablet were observed by employing scanning electron microscope where the surface of the tablet was found to be smooth from the in vitro dissolution study, combination of AG (30 mg) with PVP (30 mg), and starch used as a filler has sustained the release of drug up to 10 h.Conclusion: Therefore, developed polymeric matrix tablet exhibited enhanced potency over a conventional tablet by exhibiting an excellent dissolution profile for a period of 10 h.
Authors and Affiliations
Ruchi Sunayana S, Gowda Dv, Vishal Gupta N, Praveen Sivadasu, Manjunath M
Keywords
Related Articles
- EP ID EP605183
- DOI 10.22159/ajpcr.2018.v11i12.26301
- Views 101
- Downloads 0
SYNTHESIS OF SOME NOVEL (E)-METHYL 2,4-DIMETHYL-5-(3-OXO-3-PHENYLPROP-1-EN-1- YL)-1H-PYRROLE-3-CARBOXYLATE DERIVATIVES AS ANTIMICROBIAL AGENT
Objective: The objective of the present study was to synthesize a series of some novel (E)-methyl 2,4-dimethyl-5-(3-oxo-3-phenylprop-1-en-1-yl)-1H-pyrrole-3-carboxylate derivatives and to evaluate it’s in vitro antimicro...
COMPARISON OF THE EFFECTS OF NIGELLA SATIVA OIL AND LASER ON TREATMENTS ON EXPERIMENTAL WOUND HEALING IN RATS
Objective:The study investigated the influences of treatment with Nigella sativa oil and laser therapy on wound healing in rats. The period of the inflammatory phase reduced through both laser and N. sativa oil actions;...
RECENT UPDATE ON PRONIOSOMAL GEL AS TOPICAL DRUG DELIVERY SYSTEM
An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. Newer drugs of lipophilic nature emerge poor bio...
SANSEVIERIA HYACINTHOIDES (L.) DRUCE: A REVIEW OF ITS BOTANY, MEDICINAL USES, PHYTOCHEMISTRY, AND BIOLOGICAL ACTIVITIES
Sansevieria hyacinthoides is a succulent perennial herb widely used as herbal medicine. This study is aimed at providing a critical review of the botany, biological activities, phytochemistry, and medicinal uses of S. hy...
DEFLUORIDATION TECHNIQUES- A CRITICAL REVIEW
Fluoride in drinking water plays a vital role in dental health. Due to excessive fluoride in water, enamel loses its luster. At lower concentration, it guards our teeth against cavities but at higher concentrations impar...