FORMULATION DEVELOPMENT AND EVALUATION OF DILTIAZEM HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLET.
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract The aim of the current study was to design sustained release tablet of Diltiazem hydrochloride and to optimize the drug release profile and dissolution time using response surface methodology. Diltiazem hydrochloride is an antihypertensive drug, a benzothiazepine derivative with vasodilating action. It is prescribed for the treatment of hypertension and other cardiovascular disorder. Antihypertensive should continue for several months. Diltiazem hydrochloride has half-life of 3-4.5 hours. So its chronic use necessitates the sustained release formulation to reduce dose and dosing frequency. A 32 full factorial design (2 factors at 3 levels each) was employed to systematically optimize the drug release profile. Kollidon SR and HPMC K100 were taken as the independent variables. The % drug release at 4 hr and % drug release at 24 hr were dependent variables .Tablets were prepared by direct compression and evaluated for Hardness, Friability, Percent drug content and In-vitro drug release pattern. Both the polymers had significant effect on the drug release and of the tablets. All the formulation release the drug for more than 24 hours. The optimized formulation F6 having Kollidon SR 135mg and HPMC K100 105mg showed maximum release of 98.70 % drug release for 24 hr. Most of the formulation followed Higuchi Model.so sustained release tablet of diltiazem HCl was formed which provide drug release for 24 Hrs.
Authors and Affiliations
D V Derle1, R S Barhate1*, P A Umberkar1, N D Derle2
Keywords
Related Articles
- EP ID EP330698
- DOI -
- Views 95
- Downloads 0
TOTAL PHENOLIC CONTENTS AND ANTIOXIDANT ACTIVITY OF METHANOL EXTRACT FROM LEAVES, FLOWERS AND STEMS OF WARIONIASAHARAEL. FROM MORROCCO
The phenolic contents of metabolic extracts of WarioniasaharaeL leaves, flowers and stems from Morocco were measured in this work. The antioxidant activities of these extracts were also evaluated. The leaves methanolextr...
SURVELLIANCE OF BOVINE MILK SAMPLES AND DETERMINED ITS IMMUNOLOGICAL ACTIVITY OF LACTOFERRIN
Abstract Milk is a very complex product and reported more than hundred separate chemical compounds. The major components of milk are water, casein, whey proteins, fat, lactose and minerals. These components should be var...
FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE TRANSDERMAL PATCH
Transdermal drug delivery systems (TDDS) are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. In the current research Diltiazem hydrochloride was loaded in transdermal...
FORMULATION AND EVALUATION OF OMEPRAZOLE MICROSPHERES BY DIFFERENT TECHNIQUES
Abstract The intention behind the present work was to develop a microsphere based novel dosage form for sustained delivery of Omeprazole. Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by sp...
A STUDY ON PROTECTIVE ROLE OF PRUNUS AMYGDALUS ON ALCOHOL INDUCED RETROGRADE AMNESIA
Abstract Ethanol and Prunus amygdalus (PA) are most widely used in the world. PA is a popular nourishing food, along with its nutritional values it also possess medicinal values like anti-stress, anti oxidant, immunostim...