FORMULATION DEVELOPMENT AND EVALUATION OF DILTIAZEM HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLET.
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract The aim of the current study was to design sustained release tablet of Diltiazem hydrochloride and to optimize the drug release profile and dissolution time using response surface methodology. Diltiazem hydrochloride is an antihypertensive drug, a benzothiazepine derivative with vasodilating action. It is prescribed for the treatment of hypertension and other cardiovascular disorder. Antihypertensive should continue for several months. Diltiazem hydrochloride has half-life of 3-4.5 hours. So its chronic use necessitates the sustained release formulation to reduce dose and dosing frequency. A 32 full factorial design (2 factors at 3 levels each) was employed to systematically optimize the drug release profile. Kollidon SR and HPMC K100 were taken as the independent variables. The % drug release at 4 hr and % drug release at 24 hr were dependent variables .Tablets were prepared by direct compression and evaluated for Hardness, Friability, Percent drug content and In-vitro drug release pattern. Both the polymers had significant effect on the drug release and of the tablets. All the formulation release the drug for more than 24 hours. The optimized formulation F6 having Kollidon SR 135mg and HPMC K100 105mg showed maximum release of 98.70 % drug release for 24 hr. Most of the formulation followed Higuchi Model.so sustained release tablet of diltiazem HCl was formed which provide drug release for 24 Hrs.
Authors and Affiliations
D V Derle1, R S Barhate1*, P A Umberkar1, N D Derle2
Keywords
Related Articles
- EP ID EP330698
- DOI -
- Views 83
- Downloads 0
A review: Liposome drug delivery system
Liposomes are the smallest artificial vesicles of spherical shape that can be produced from natural untoxic phospholipids and cholesterol. Liposomes are concentric bilayered vesicles in which aqueous volume is entirely e...
A review;Vesicular drug delivery-an novel approach
Novel drug delivery system aims to provide some control in temporal or spatial nature of the drug release in the body. In recent years, vesicle have been the vehicle of choice in drug delivery for targeting and controlle...
“APPRAISAL OF ANTIBIOTICS USE IN A SECONDARY CARE HOSPITAL IN SOUTH INDIA.
Abstract The emergence of antibiotic resistant bacteria is major problem throughout the world and rational use of antibiotics is therefore very important. Good infection control practice is a critical component for succe...
PHARMACOVIGILANCE PROGRAMME IN INDIA PRESENT CIRCUMSTANCE AND ITS PERSPECTIVES
Adverse drug reaction (ADR) is defined as any response to a drug which is harmful and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease, or for the modification...
Analytical Method Development and Validation for Simultaneous Determination of Bisoprolol Fumarate and Amlodipine Besylate
A fast, robust RP-HPLC method was developed for simultaneous determination of Bisoprolol fumarate and Amlodipine besylate in tablets. The mobile phase was mixture of Methanol: Acetonitrile: 50mM Potassium dihydrogen phos...