FORMULATION, DEVELOPMENT AND EVALUATION OF DOXOPHYLLINE SUSTAINED RELEASE MATRIX TABLET
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
The study was done with an objective to achieve a potential sustained and controlled release oral drug delivery system of a antiasthmatic drug, doxophylline which having shorter half life. Hydroxypropyl methyl cellulose was used for gel forming agent. Differential scanning calorimeter (DSC) study show that drug and other excipints are compatible with each other. The tablets were evaluated for physical characteristic like hardness, weight variation, fraibilty, and thickness. It was found that drug release rate increased with the amount of osmogent because of the increased water uptake and hence increased driving force for drug release. Accelerated stability study was also performed for three months indicated that optimized formulation was stable. Use of HPMC as the total matrix material significantly influenced the release rate of the drug. Addition of different diluents like magnesium stearate and microcrystalline cellulose were used for improving flow ability and compressibility. Based on dissolution studies all the formulations showed sustained release of drugs from the formulations.
Authors and Affiliations
Hima Pandya , Akshay Patel , Janki Bodiwala
Keywords
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