FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLET OF RAMIPRIL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 8
Abstract
Objective: The aim of this study was to prepare fast dissolving tablet of Ramipril by using Sodium starch glycolate, and Crospovidone as superdisintegrants to enhance the dissolution rate and the disintegration rate and evaluated for Pre and Post Compression parameter of the tablet.Methods: Fast dissolving tablet of Ramipril was prepared by direct compression technique. Fast dissolving tablet was evaluated for Pre compression parameter; bulk density, tapped density, Hausner’s ratio, angle of repose and Carr’s index and post compression parameter; weight variation, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time and dissolution time. The UV-spectrophotometric method has been used for the quantitation of drug release of Ramipril in the Fast dissolving tablet formulation.Results: Pre and post compression parameter were evaluated. Five different batches of tablets, F1 to F5 were prepared. Bulk density and tapped density was found in the range of 0.64-0.85 g/cm3 and 0.68-0.98 g/cm3 simultaneously. The hardness, friability, wetting time, the water absorption ratio, disintegration and dissolution time were found to be acceptable according to the standard limit and compare to all formulations F4 formulation was selected as the promising formulation. All batches of fast dissolving tablet were satisfactory in term of dissolution. The cumulative percentage of drug release of F4 formulation was 90.12% after 12 min compare to other formulation.Conclusion: The result suggested that the dissolution and disintegration of Ramipril have improved considerably in batch F4 formulation as compared to rest of the formulation. The dissolution rate and dissolution rate of Ramipril can be enhanced to a great extent by the direct compression technique with the addition of superdisintegrants.
Authors and Affiliations
Amrita Soni, Vaibhav Rajoriya, Varsha Kashaw
Keywords
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