FORMULATION DEVELOPMENT AND IN VIVO EVALUATION OF NEVIRAPINE SOLID DISPERSIONS BY SOLVENT EVAPORATION TECHNIQUE
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2018, Vol 10, Issue 3
Abstract
The objective of the present investigation is focused on the preparation of solid dispersions containing Nevirapine. The effect of various hydrophilic polymers on the aqueous solubility was studied. Kolliphor P188 was selected as carrier and solid dispersions were prepared by solvent evaporation technique. Evaluation of solid dispersion for percentage yield, drug content and solubility were most appropriate. Solid dispersions of drug: Kolliphor P188 and SLS (1:3:1 ratio) (SE9) shown higher dissolution rate i.e. 98.6% compared with and pure drug (37.5%) and other formulations. Powder X-ray diffraction performed on solid dispersion showed that Nevirapine existed in the amorphous form within the solid dispersion formulation fabricated using the solvent evaporation process. Additionally, scanning electron microscopy studies suggested the conversion of crystalline Nevirapine to an amorphous form. Therefore, the solid dispersions prepared by solvent evaporation method using Kolliphor P188 as hydrophilic carrier can be successfully used for improvement of solubility and dissolution of Nevirapine. Both in vitro dissolution testing and the in vivo studies demonstrated that the solubility and bioavailability of Nevirapine were significantly improved when formulated in a solid dispersion with Kolliphor P188 and SLS. The present study demonstrated that formulation of Nevirapine solid dispersion by solvent evaporation technique is a highly effective strategy for enhancing the bioavailability of poorly water soluble Nevirapine.
Authors and Affiliations
Medipalli Viswaja, D. V. R. N Bhikshapathi
Keywords
Related Articles
- EP ID EP618400
- DOI 10.25004/IJPSDR.2018.100304
- Views 88
- Downloads 0
SYNERGISTIC ANTIHYPERLIPIDEMIC ACTIVITY OF SALACIA OBLONGA, SALACIA ROXBHURGII AND LAGERSTROEMIA PARVIFLORA
The present study aimed that evaluation antihyperlipidemic activity of Salacia oblonga, Salacia roxbhurgii and Lagerstroemia parviflora individually and combined plants extracted poly herbal extraction and screened for p...
IDENTIFICATION OF CHEMICAL COMPOUNDS FROM THE ETHANOLIC EXTRACT OF THE BARK OF BAUHINIA TOMENTOSA L. BY GC-MS ANALYSIS
The bark of Bauhinia tomentosa L. is used wildly used for the treatment of varies ailments such as inflammation, wound, dysentery, skin diseases and for microbial infections. In the present study the ethanolic extract of...
THE NEWLY DEVELOPED HIGHLY SENSITIVE METHOD FOR THE DETERMINATION OF CAPECITABINE BY USING UV-SPECTROSCOPY
Capecitabine is a fluoropyrimidine carbamate, designed as 'pro-drug' to the cytotoxic agent 5-fluorouracil (5-FU) meant to be administered orally. Capecitabine is used as first line monotherapy for metastatic colorectal...
SOLUBILITY ENHANCEMENT OF ARIPIPRAZOLE BY SOLID-SELF EMULSIFYING DRUG DELIVERY SYSTEMS
Self-emulsifying drug delivery systems are a promising approach for the formulation of drug compounds with poor aqueous solubility. The main objective of this work was to formulate liquid and solid-self emulsifying drug...
FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF STAVUDINE GASTRO RETENTIVE FLOATING MATRIX TABLETS
The aim of the present investigation was to develop floating matrix tablets of stavudine to achieve prolong gastric residence time, leading to an increase in drug bioavailability and patient compliance. Floating tablets...