FORMULATION, DEVELOPMENT AND OPTIMIZATION OF MODIFIED RELEASING PELLETS OF DRUG CARVEDILOL
Journal Title: International Journal of Drug Regulatory Affairs - Year 2017, Vol 5, Issue 4
Abstract
The main objectives of present work was to design and evaluate modified releasing pellets of drug, Carvedilol, in respect to increase patient compliance and therapeutically benefits. The modified releasing pellets were made by the sub-coating with sodium bicarbonate and hydroxyl propyl methyl cellulose which was utilized to keep the spheres in stomach for long time. To get modified release of active pharmaceutical ingredients from the pelletizing process, they were coated with methacrylic acid co-polymer (Eudragit NE 40D). Hence sodium bicarbonate, hydroxyl propyl methyl cellulose and eudragit NE 40D are the key ingredients of this dissertation work. Concentration of sodium bicarbonate, hydroxyl propyl methyl cellulose and eudragit NE 40D in coating suspension was optimized by initial studies and factorial design. The procedure based optimization analysis also perform to optimize process factors like product temperature and spraying rate to improve physical parameters and micromeritic characteristics of spheres by preliminary data.
Authors and Affiliations
Kurnool Abdul Nasir, Rakesh Kumar Jat, Narendra C
Keywords
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- EP ID EP329108
- DOI 10.22270/ijdra.v5i4.208
- Views 117
- Downloads 0
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