FORMULATION, EVALUATION AND SOLID-STATE THERMOGRAPHIC CHARACTERIZATION OF CFC FREE BECLOMETASONE DIPROPIONATE PRESSURIZED METERED DOSE INHALATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: In view of the aim, the objective of the present work was to develop a solution based pulmonary drug delivery system containing Beclometasone dipropionate 250mcg using a Hydrofluoroalkane (HFA 134a and HFA 227ea), a non-chlorofluorocarbon, as propellant to be administered as pressurized metered dose inhalation (pMDI) for direct and targeted delivery of the drug to the lungs and to evaluate the effect of formulation variables on its efficacy and stability. Methods: In the formulations, 0.015 % oleic acid and 14% of ethanol were used as surfactant and co-solvent respectively. To assure stability of the formulations various quality control tests were performed. Quantitative estimation was done by HPLC method, In-vitro drug deposition studies was carried out using Anderson cascade impactor and the particle characterization was done by using Twin impinge. Thermographic characterization was done by DSC. Results: The formulation with HFA 227ea was found to be more stable than the formulation containing HFA 134a in three months study period. DF 316 valves with 50µl spraying capacity having pp actuator systems were found to encompass acceptable results for dosage test or pump delivery and leak test with better fine dose respirable fraction. DSC indicated solid-state property of a net respirable fraction and thermograhic characterization of the particle emitted from optimized formulations. Conclusion: The formulation may be an attempt to develop pulmonary administrable product of Beclometasone dipropionate in form of pMDI using an eco-friendly chlorine-free propellant HFA 227ea as hydrofluoro alkanes were found to be the stable and robust for obtaining the desired attributes to meet the packaging requirements.
Authors and Affiliations
Snigdha Pattnaik, Niyogi Partha, Maharana Laxmidhar, Panigrahi Lalatendu
Keywords
Related Articles
- EP ID EP579738
- DOI -
- Views 56
- Downloads 0
IN SILICO ANALYSIS OF STRUCTURAL REQUIREMENTS FOR THIOPHENE DERIVATIVES AGAINST POLO LIKE KINASE-1 (PLK1)
Objective: Development of anti-mitotic drugs for chemotherapy of cancer has been one of the main focuses of research in 21st century. Present work aims to study the structural requirements of thiophene derivatives agains...
ANTIPROLIFERATIVE EFFECT AND SELECTIVITY OF SODIUM DICHLORO-BIS [N-PHENYL-5-CHLORO-SALICYLIDENEIMINATO-N, O] RUTHENATE (III) IN VITRO
Ruthenium complexes attracted special attention in recent decades due to their anticancer properties. Since a number of Ru(III) complexes with Schiff bases showed moderate activity to bind DNA, antiproliferative effect o...
DEVELOPMENT OF COLON-SPECIFIC MULTI PARTICULATE DRUG DELIVERY SYSTEM OF FENOVERINE
Objective: The main objective of this study was to formulate and evaluate colon-specific multi- particulate drug delivery system of fenoverine, using Eudragit S 100 as enteric coating polymer.Methods: Microparticles were...
LANNEA BARTERI ENGL. (ANACARDIACEAE) PLANT USED IN THE TREATMENT OF URINARY TRACT INFECTIONS IN IVORY COAST: BIOLOGICAL AND CHEMICAL STUDIES OF THE AQUEOUS EXTRACT
Objective: This research aims to evaluate the antibacterial activity and determine the chemical composition of the aqueous extract of the bark of Lannea barteri Engl. (DA) used in the traditional treatment of urinary tra...
ATORVASTATIN VS ROSUVASTATIN; FENOFIBRATE AS AN ADD ON: AN EXPLORATORY STUDY
Objective: Statins being the first choice drug for dyslipidaemia, the quest for better one among all has always been and still a question for research in the field of medicine. Objective The objective of our study was...