FORMULATION, EVALUATION AND SOLID-STATE THERMOGRAPHIC CHARACTERIZATION OF CFC FREE BECLOMETASONE DIPROPIONATE PRESSURIZED METERED DOSE INHALATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: In view of the aim, the objective of the present work was to develop a solution based pulmonary drug delivery system containing Beclometasone dipropionate 250mcg using a Hydrofluoroalkane (HFA 134a and HFA 227ea), a non-chlorofluorocarbon, as propellant to be administered as pressurized metered dose inhalation (pMDI) for direct and targeted delivery of the drug to the lungs and to evaluate the effect of formulation variables on its efficacy and stability. Methods: In the formulations, 0.015 % oleic acid and 14% of ethanol were used as surfactant and co-solvent respectively. To assure stability of the formulations various quality control tests were performed. Quantitative estimation was done by HPLC method, In-vitro drug deposition studies was carried out using Anderson cascade impactor and the particle characterization was done by using Twin impinge. Thermographic characterization was done by DSC. Results: The formulation with HFA 227ea was found to be more stable than the formulation containing HFA 134a in three months study period. DF 316 valves with 50µl spraying capacity having pp actuator systems were found to encompass acceptable results for dosage test or pump delivery and leak test with better fine dose respirable fraction. DSC indicated solid-state property of a net respirable fraction and thermograhic characterization of the particle emitted from optimized formulations. Conclusion: The formulation may be an attempt to develop pulmonary administrable product of Beclometasone dipropionate in form of pMDI using an eco-friendly chlorine-free propellant HFA 227ea as hydrofluoro alkanes were found to be the stable and robust for obtaining the desired attributes to meet the packaging requirements.
Authors and Affiliations
Snigdha Pattnaik, Niyogi Partha, Maharana Laxmidhar, Panigrahi Lalatendu
Keywords
Related Articles
- EP ID EP579738
- DOI -
- Views 49
- Downloads 0
EVALUATION OF IN VITROANTICANCER ACTIVITY AND GC-MS ANALYSIS FROM LEAF SOPHORA INTERRUPTA BEDD
Objective: Sophora interrupta Bedd (Fabaceae) is one of the well-known medicinal herb used in folk medicine for the treatment of cancer and inflammatory associated diseases. In this paper we aimed to evaluate the antioxi...
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF EPERISONE HYDROCHLORIDE IN BULK DRUG
Objective: A new, economical, precise and accurate stability indicating HPTLC method was developed and validated for the determination of Eperisone hydrochloride in bulk drug.Methods: Sample and standard solutions of Epe...
PHYTOCHEMICAL SCREENING, ANTIOXIDANT ACTIVITY OF PURE SYRINGIN IN COMPARISON TO VARIOUS SOLVENTS EXTRACTS OF MUSA PARADISIACA (BANANA) (FRUIT AND FLOWER) AND TOTAL PHENOLIC CONTENTS
Objective: The study concentrated on exploring the radical scavenging activity of various banana extracts in comparison to pure syringin and the total phenolic contents of the extracts.Methods: The banana parts were prep...
COST-EFFECTIVENESS ANALYSIS OF TRASTUZUMAB IN THE TREATMENT OF METASTATIC BREAST CANCER
Objective: To perform a cost-effectiveness analysis of pharmacological treatments for MBC in the context of the Brazilian Unified Health System (Sistema Único de Saúde - SUS) by comparing the drugs docetaxel and paclit...
PREVENTION OF OBESITY AND DEVELOPMENT OF METABOLIC SYNDROME BY MANGOSTEEN (GARCINIA MANGOSTANA L.) PERICARP ETHANOLIC EXTRACT IN MALE WISTAR RATS FED WITH HIGH-FAT DIET
Objective: This study was conducted to evaluate the mangosteen (Garcinia mangostana) pericarp ethanolic extract (MPEE) properties in preventing obesity as well as its associated metabolic syndrome by analyzing the liver...