FORMULATION OF LEVOFLOXACIN AS ORODISPERSIBLE TABLETS USING A READY-MADE BLEND OF EXCIPIENTS COMPARED WITH CLASSIC FORMULATION STRATEGIES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: Orodispersible tablets are designed to undergo rapid dispersal when they are placed in the mouth prior to being swallowed. The aim of this study was to compare the performance of a ready-made excipients blend designed for orodispersible tablets with several other conventional methods for the manufacture of tablets using levofloxacin as the active pharmaceutical ingredient.Methods: Several different formulas were prepared to compare the powder characteristics, and the resulting powders were compressed into tablets using the direct compression method. The result compressed tablets was then evaluated in terms of their physical characteristics and drug release properties.Results: The results of these experiments showed that the use of ready-made blend provided several advantages over the conventional methods in terms of physical properties of the powders and tablets, as well as their drug release and dissolution properties.Conclusion: The use of a ready-made powder blend in formulation of ODT of model drug levofloxacin had an advantage over the classic methods of formulation.Â
Authors and Affiliations
Israa H. Al-ani
Keywords
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- EP ID EP578286
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