FORMULATION, OPTIMIZATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF DOMPERIDONE
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2015, Vol 3, Issue 9
Abstract
Fast dissolving dosage form (FDDF) is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such formulation readily dissolve or disintegrate in the saliva generally within <60seconds. Fast dissolving Systems are useful for pediatric, geriatric, and bedridden patients and for patients who are suffered with Dysphasia. This fast dissolving drug delivery system (FDDS) is suited for the drugs which undergo high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to mouth plasma peak levels, which in turn minimize adverse/side effects. Some drugs are absorbed well from the mouth, pharynx and esophagus as the saliva passes down into the stomach. In such cases, bioavailability of drug is significantly greater than those observed from conventional tablet dosage form. Most fast-dissolving delivery system films must include substances to mask the taste of the active ingredient. This masked active ingredient is then swallowed by the patient's saliva along with the soluble and insoluble excipients. The sublingual and buccal delivery of a drug via oral film has the potential to improve the onset of action, lower the dosing, and enhance the efficacy and safety profile of the medicament. In this paper we have compared fast dissolving tablet and fast dissolving oral film.
Authors and Affiliations
Navneet Kumar Verma*| Department of Pharmacy, Kailash Institute of Pharmacy & Management, Gorakhpur, Uttar Pradesh, India, Pin-273209, Shivendra Pratap Singh| Department of Pharmacy, Kailash Institute of Pharmacy & Management, Gorakhpur, Uttar Pradesh, India, Pin-273209, Abhay Pratap Singh| Department of Pharmacy, Kailash Institute of Pharmacy & Management, Gorakhpur, Uttar Pradesh, India, Pin-273209, Praveen Kumar Rai| Department of Pharmacy, Kailash Institute of Pharmacy & Management, Gorakhpur, Uttar Pradesh, India, Pin-273209, Reena Singh| Department of Pharmacy, Kailash Institute of Pharmacy & Management, Gorakhpur, Uttar Pradesh, India, Pin-273209
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