Fosfomycin as an alternative therapeutic option for treatment of infections caused by multi-resistant Gram-negative bacteria
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 8, Issue 2
Abstract
The problem of significantly reduced drug use concerns particularly the infections caused by multi-resistant pathogens, especially Gram-negative bacteria. In this regard, interest is increasing in the known for nearly 50 years, but now frequently forgotten antibiotic – fosfomycin. Fosfomycin possesses high effectiveness for multidrug-resistant bacteria, comprising of extended-spectrum β-lactamases (ESBL), Klebsiella pneumoniae carbapenemases (KPC); commonly, the pandrug-resistant (PDR) and the extensively drug-resistant (XDR) strains, especially from Enterobacteriaceae family. Because of facilitated distribution into inflamed tissues and a very broad range of in vitro bactericidal activity, fosfomycin may have various applications in the treatment of many kinds of bacterial infections, including acute uncomplicated infections of the urinary bladder or complicated urinary tract infections, urinary tract sepsis, pyelonephritis, cystitis, prostatitis and chronic lung infections in patients with cystic fibrosis, the great majority caused by multi-resistant Gram-negative bacteria, and in the therapy eradicating multidrug-resistant Helicobacter pylori. Fosfomycin may limit the toxicity of other antibiotics and play a protective role in the process of bacterial resistance development during the therapy. Combinations of different antimicrobials enable the use of forgotten antibiotics in commonly occurring infections, although they are still completely incurable.
Authors and Affiliations
Zdzieblo Magdalena, Sylwia Andrzejczuk, Beata Chudzik-Rząd, Marek Juda, Anna Malm
Keywords
Related Articles
- EP ID EP58811
- DOI -
- Views 169
- Downloads 0
Contact eczema of hands caused by contact with potato protein
[b]Introduction. [/b]Protein contact dermatitis (PCD) is an IgE-dependent allergic reaction which, despite enormous progress in knowledge, remains a ‘non-diagnosed’ nosologic unit in contemporary medicine. Skin lesion, w...
Nutrition-related health behaviours and prevalence of overweight and obesity among Polish children and adolescents
Introduction. An adequate mode of nutrition is among the most important environmental factors affecting the development of Man and maintenance of a good health status. An improper selection of nutrients and irregular con...
First case of human granulocytic anaplasmosis from Slovakia.
In order to evaluate the potential risks of human granulocytic anaplasmosis in Slovakia, blood and serum samples of hunters and foresters from the northern parth of Slovakia were tested. We present the first case of HGA...
Past obstetric history and risk of ovarian cancer
Introduction: Early age at menarche and late age at last menstrual period, as well as other reproductive factors, may be the cause of development of some types of cancer concerning the female reproductive organs. It has...
Bacillus anthracis infections – new possibilities of treatment
[b]Introduction and objective[/b]. [i]Bacillus anthracis[/i] is one of biological agents which may be used in bioterrorism attacks. The aim of this study a review of the new treatment possibilities of anthrax, with parti...