Frequencies of the Arg16Gly, Gln27Glu and Thr164Ile Adrenoceptor β2 Polymorphisms among Omanis

Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 4

Abstract

Objectives: Tis study aimed to assess the distribution of missense mutations in the adrenoceptor β2 (ADRB2) gene in an Omani cohort. Methods: Tis study was carried out between May 2014 and March 2015 at the Sultan Qaboos University, Muscat, Oman. Blood samples were taken from 316 unrelated Omani subjects. Genotyping for rs1042713 (c.46A>G, p.Arg16Gly), rs1042714 (c.79C>G, p.Gln27Glu) and rs1800888 (c.491C>T, p.Tr164Ile) polymorphisms was performed by real-time polymerase chain reaction using single nucleotide polymorphism (SNP) genotyping assays. Te allelic frequencies of these polymorphisms were estimated on the basis of the observed numbers of specifc alleles from the genotype data for male and female subjects. Te genotype frequencies for each polymorphism were tested for deviation from the Hardy-Weinberg equilibrium. Results: Gly16 and Glu27 were the most frequent variants found among the cohort (63% and 75%, respectively). Te Ile164 variant was not detected in the study population. Tere was a signifcant linkage disequilibrium between the rs1042713 and rs1042714 SNPs (r2 = 0.209; P ≤0.001). Te most observed haplotypes were Gly16-Gln27 and Arg16-Gln27 (0.37 and 0.38, respectively). Te frequency of Gly16-Glu27 was 0.25, comprising all Glu27 carriers. Conclusion: Te allelic distribution of variants in this Omani cohort was similar to distributions reported among Caucasian populations.

Authors and Affiliations

Khalid Al-Balushi| Departments of 1Pharmacology & Clinical Pharmacy, Fahad Zadjali| Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Sawsan Al-Sinani| Department of Laboratory Medicine & Pathology, Royal Hospital, Muscat, Oman, Al-Muatasim Al-Zadjali| Department of Small Animal Health, Directorate General of Veterinary Services, Royal Court Affairs, Muscat, Oman, Riad Bayoumi| Department of Basic Medical Sciences, Dubai Healthcare City, Dubai, United Arab Emirates

Keywords

Related Articles

Snoring-Induced Nerve Lesions in the Upper Airway

Te prevalence of habitual snoring is extremely high in the general population, and is reported to be roughly 40% in men and 20% in women. Te low-frequency vibrations of snoring may cause physical trauma and, more speci...

Complicated Subacute Bacterial Endocarditis in a Patient with Ventricular Septal Defect

Infective endocarditis (IE) is an uncommon but life-threatening infection. Despite advances in management, it still causes high morbidity and mortality. We report the case of an 8-year-old girl who presented with a pro...

Single-Incision Multi-Port Appendectomy for a Patient with Situs Inversus Totalis First case report

Situs inversus totalis (SIT) is a rare autosomal recessive condition involving the complete lateral transposition of the organs. When individuals with this condition suffer from appendicitis, associated pain and sympt...

Therapy with radionuclides, clinical acceptance is overdue

In this issue, Drs. Bererhi and Constable‘ have published an important paper on the radiation doses received by relatives of patients after radioiodine therapy for thyroid cancer or for hyperthyroid Graves' disease. Ba...

The p53 Mutation/Deletion Profle in a Small Cohort of the Omani Population with Diffuse Large B-Cell Lymphoma

Objectives: Mutations/deletions affecting the TP53 gene are considered an independent marker predicting a poor prognosis for patients with diffuse large B-cell lymphoma (DLBCL). A cohort within a genetically isolated...

Download PDF file
  • EP ID EP14609
  • DOI -
  • Views 333
  • Downloads 13

How To Cite

Khalid Al-Balushi, Fahad Zadjali, Sawsan Al-Sinani, Al-Muatasim Al-Zadjali, Riad Bayoumi (2015). Frequencies of the Arg16Gly, Gln27Glu and Thr164Ile Adrenoceptor β2 Polymorphisms among Omanis. Sultan Qaboos University Medical Journal, 15(4), 486-490. https://europub.co.uk/articles/-A-14609