Frequency and Sensitivity of Extended Spectrum Beta-Lactamase Positive Organisms in a Secondary and Tertiary Level Hospital Network in Dhaka
Journal Title: Journal of Enam Meical College - Year 2015, Vol 5, Issue 2
Abstract
Background: Extended spectrum β-lactamase (ESBL) positive organisms are now a global health concern including in Bangladesh. These are associated with treatment failure, increased morbidity and mortality and increased health care costs. In this study, frequency of ESBL positive organisms in some health care centres in Dhaka city has been observed and their current status of antibiogram has also been observed. Objective: To observe the current status of antibiogram of ESBL positive organisms. Materials and Methods: This cross-sectional study was done in the Department of Microbiology, Bangladesh Institute of Health Sciences (BIHS) General Hospital, Dhaka, Bangladesh from March, 2012 to February, 2013. Only E. coli and Klebsiella spp. from pus and urine specimens were included in this study. Isolation, identification and antibiotic sensitivity of the organisms were done by standard procedures. Results: Organisms (Escherichia coli and Klebsiella spp.) isolated from urine and pus collected from different sites of 472 subjects were studied. Predominant organisms were Escherichia coli (82.8%) and remaining 17.2% were Klebsiella spp. ESBL positive organisms were higher in Escherichia coli (54.5%) than in Klebsiella spp. (44.4%) and higher in pus (77.0%) than in urine (49.1%) isolates. Imipenem is the most effective drug for treating ESBL positive organisms followed by colistin, tigecycline and piperacillin/tazobactam. Conclusion: Imipenem, colistin, tigecycline and piperacillin/tazobactam drugs should be kept reserved and used only when other effective drugs are not available so that emergence of resistance against these drugs is deferred. While reporting the culture and sensitivity tests, the ESBL positive organisms should be pointed out with comment like this – “The organisms are ESBL positive and resistant to penicillins, cephalosporins and monobactams”.
Authors and Affiliations
Shah Md Zahurul Haque Asna, Shameem Akhter, M Mushfequr Rahman, Najib Mohammad, MA Hafez
Keywords
Related Articles
- EP ID EP36227
- DOI https://doi.org/10.3329/jemc.v5i2.23377
- Views 320
- Downloads 0
https://www.banglajol.info/index.php/JEMC/article/view/27766/18497
Nipah virus, a member of the genus Henipavirus, a new class of virus in the Paramyxoviridae family, has drawn attention as an emerging zoonotic virus in South-East and South Asian region. Case fatality rate of Nipah vi...
Sulfasalazine-Induced Pancytopenia in Ulcerative Colitis
Sulfasalazine is a well-established disease-modifying agent. It is commonly used in the treatment of rheumatic disorders and inflammatory bowel disease. The most frequently reported adverse effects are gastrointestinal...
Scenario of Fine Needle Aspiration Cytology of Neck Masses in a Tertiary Care Hospital
Background: Masses in the neck are very common and these may range from inflammatory to neoplastic lesions. Fine needle aspiration cytology (FNAC) is a simple, quick and minimally invasive procedure that is well recogniz...
Acute Retrograde Jejunogastric Intussusception
A 65-year-old male was admitted into Enam Medical College Hospital through emergency unit with severe upper abdominal colicky pain, paroxysms of haematemesis and constipation for one day. He had undergone gastric sur...
Congentital Cystic Adenomatoid Malformation in a Two-Month-Old Infant
No Abstract