Frequency of Bone Marrow Involvement in Different Stages of Diffuse Large B cell Lymphoma (Dlbcl)
Journal Title: Isra Medical Journal - Year 2018, Vol 10, Issue 4
Abstract
OBJECTIVE: To assess the frequency of bone marrow involvement in different stages of diffuse large B cell lymphoma patients. STUDY DESIGN: A cross sectional interventional study. PLACE AND DURATION: At Oncology Department of Combined Military Hospital Rawalpindi, from 15th Jan 2015 to 30th Oct 2015. METHODOLOGY: One hundred and twenty one patients were selected by purposive sampling technique. Diagnostic and staging work-up excluding bone marrow biopsy was done. Then all patients were subjected to the unilateral iliac bone marrow trephine biopsy. Samples were examined to see its invasion by lymphoma. Stage wise involvement of bone marrow was recorded and frequency of bone marrow involvement in different stages was calculated. RESULTS: Out of 121 patients, 33.8% were stage I, 30.6% stage II, 27.3% stage III and 8.3% were stage IV (excluding bone marrow examination). Stage wise involvement of bone marrow on trephine biopsy was 12%, 42%, 54% and 80% for stage I, II, III and IV respectively. Combined early stage (Stage I and II) patients had bone marrow involvement in 20% of cases. CONCLUSION: Stage wise bone marrow involvement in cases of diffuse large B cell lymphoma, is higher in patients presenting to our hospital, than reported in International literature. Exact cause of this increase in frequency should be determined by further studies. KEYWORDS: Bone Marrow, Trephine Biopsy, Diffuse Large Cell Lymphoma, Non-Hodgkin’s Lymphoma, Lymphoproliferative Disease, Lymphoma Staging HOW TO CITE THIS: Nadeem MS, Haider N, Rasul S, Ali U, Khan MY. Frequency of Bone Marrow Involvement in Different Stages of Diffuse Large B cell Lymphoma (Dlbcl). Isra Med J. 2018; 10(4): 212-215.
Authors and Affiliations
Muhammad Sohaib Nadeem
Keywords
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