Frequency of chemokine receptor variants linked to HIV infection susceptibility among infected individuals and their sexual partners
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 10
Abstract
<b>Introduction.</b> Genetic resistance to HIV infection is important in populations with high ratio of sexual transmissions, as it modifies both immunological response and possibility of viral integration with the target cell. The aim of work was to compare the frequency of four genetic variants of chemokine receptor genes from locus 3p21 and 22: Δ32<i> CCR5</i>, A(-2459)G <i> CCR5, </i>and G744A/C838T <i> CX </i><sub>3</sub><i> CR1</i> in a group of HIV infected individuals and their discordant partners. <br><b> Material and methods.</b> Eighteen discordant heterosexual pairs with one partner HIV (+) and one HIV (-) were enrolled to the study. From all individuals DNA was extracted with subsequent PCR and PCR/RFLP analysis. Basing on the agarose gel electrophoresis of the product, frequency of the chemokine receptor variants was established.<br><b> Results.</b> <i> CCR5 </i>Δ32 allele frequency proved to be significantly higher among non-infected partners than among HIV (+) individuals (13.9% vs 0%, p=0.02). One uninfected person was homozygous for this allele; two Δ32/wt heterozygotes were identified. For the remaining variants no significant differences for genotypes and alleles were identified.<br><b> Conclusions.</b> Δ32 <i> CCR5</i>might exert a protective influence among non-infected partners of HIV (+) individuals; its frequency was notably lower in the second group. No differences in variant frequency for the remaining analysed chemokine receptor genes suggest lack or poor influence of HIV infection susceptibility. Despite the fact that genetic factors restricting susceptibility on HIV infection were described, it is important to acknowledge the fact that CXCR4 virus remains infective even for individuals with defective CCR5 coreceptor.
Authors and Affiliations
Miłosz Parczewski, Magdalena Leszczyszyn-Pynka, Dorota Bander, Anna Boroń-Kaczmarska
Keywords
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