Frequency of Mitochondrial DNA D-Loop Somatic Mutations in Patients with HTLV-I
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 8
Abstract
Human T-cell Lymphotropic virus type-1 (HTLV-1) is endemic in Northeast of Iran. Still, it is unclear that genetic background has role in infection by HTLV-1. Methods: We ascertained the frequency of mitochondrial DNA (mtDNA) D-loop region nucleotide changes in 45 HTLV-1 infected individuals and 463 healthy control subjects using Sanger sequencing method. Results: Out of totally 164 identifed single nucleotide polymorphisms (SNPs) among HTLV-1 patients, 89 SNPs found statistically signifcant in comparison to the control group (P<0.05). In this study, no deletion was identifed in mtDNA D-loop region. But, for the frst time a high frequency of point mutations was observed in HTLV-1 patients. Conclusion: Such nucleotide changes in HTLV-1 patients propose that these mutations may result in impaired mitochondria function directly and/or indirectly. Moreover, these variations may act as a predisposing factor along with the environmental factors, and might play an important role in pathogenesis of HTLV-1.
Authors and Affiliations
Toktam Zolfaghari| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran , Department of Medical Biotechnology, Ashkezar branch Islamic Azad University, Yazd, Iran, Narges Jafarzadeh| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Arash Faal| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, EhsanGhayoor Karimiani| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Kamran Ghaffarzadehgan| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Farid Farrokhi| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Massoud Houshmand| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran, Corresponding e-mail: massoudh@nigeb.ac.ir
Keywords
Related Articles
- EP ID EP12433
- DOI -
- Views 333
- Downloads 14
Impact of Coagulase-Negative Staphylococci and Other Germs on Sperm Forms
Coagulase-negative Staphylococci (CoNS) is part of the microbiota of the male genitourinary tract, sometimes it has been considered as possible pathogenic microorganism. In the 5th version of sperm manual (WHO, 2010) sp...
DENTAL AIR FORCE HOME DENTAL CLEANING SYSTEM: A REVOLUTIONARY ORAL HYGIENE DEVICE TO PREVENT SYSTEMIC DISEASES CAUSED BY PERIODONTAL INFECTION
Aim : The study outlined to estimate the clinical, laboratory and microbiological efficacy of Dental Air Force home dental cleaning system of adult chronic periodontitis patients. Material and Method: 50 adult chronic...
RELATION BETWEEN DIABETES MELLITUS TYPE 2 AND COGNITIVE IMPAIRMENT: A PREDICTOR OF ALZHEIMER’S DISEASE
Introduction: Cognitive impairment is an important emerging problem since it is considered as the forerunner of dementia. Diabetes is one of the risk factors for dementia, but the mechanism by which it causes it is stil...
A PROSPECTIVE STUDY OF AN EFFECT OF SEPTORHINOPLASTY /RHINOPLASTY ON DEVIATED EXTERNAL NASAL PYRAMID IN KASHMIRI POPULATION
Most studies show that objective measures to quantify and determine surgical success in the treatment of External nasal deformity with /without nasal obstruction do not correlate with subjective improvement as reported...
Perceptions and Attitudes of Primary Healthcare Providers in Riyadh City, Saudi Arabia, towards the Promotion of Physical Activity
Background: Physical inactivity increases the risk of several chronic, non-communicable diseases which ultimately reduces life expectancy. Recently, major lifestyle changes in Saudi Arabia due to economic growth, global...