Frequency of Mitochondrial DNA D-Loop Somatic Mutations in Patients with HTLV-I
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 8
Abstract
Human T-cell Lymphotropic virus type-1 (HTLV-1) is endemic in Northeast of Iran. Still, it is unclear that genetic background has role in infection by HTLV-1. Methods: We ascertained the frequency of mitochondrial DNA (mtDNA) D-loop region nucleotide changes in 45 HTLV-1 infected individuals and 463 healthy control subjects using Sanger sequencing method. Results: Out of totally 164 identifed single nucleotide polymorphisms (SNPs) among HTLV-1 patients, 89 SNPs found statistically signifcant in comparison to the control group (P<0.05). In this study, no deletion was identifed in mtDNA D-loop region. But, for the frst time a high frequency of point mutations was observed in HTLV-1 patients. Conclusion: Such nucleotide changes in HTLV-1 patients propose that these mutations may result in impaired mitochondria function directly and/or indirectly. Moreover, these variations may act as a predisposing factor along with the environmental factors, and might play an important role in pathogenesis of HTLV-1.
Authors and Affiliations
Toktam Zolfaghari| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran , Department of Medical Biotechnology, Ashkezar branch Islamic Azad University, Yazd, Iran, Narges Jafarzadeh| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Arash Faal| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, EhsanGhayoor Karimiani| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Kamran Ghaffarzadehgan| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Farid Farrokhi| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Massoud Houshmand| Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran, Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran, Corresponding e-mail: massoudh@nigeb.ac.ir
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