Frequency of Rh D, C, c, E, e and Kell1 Antigens among Sudanese Patients with Sickle Cell Disease: A prospective Study from Khartoum, Sudan
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 1
Abstract
Sickle cell disease (SCD) is a group of haemoglobin disorders that increase the rate of morbidity and mortality. Blood transfusions have reduced morbidity and mortality for patients with SCD, but it can lead to erythrocyte alloimmunization the main aim in this descriptive analytical study, we determine the frequency of Rh antigens (C, D, c, E, and e) among sickle cell patients as well as to determine the frequency of kell1 antigen which will be useful in blood transfusion. The study was conducted during approximately eight months, followed informed consent, a total of 160 venous blood samples were collected from sickle cell patients in to 2.5 ml EDTA containers .All samples were tested for Rh D antigen using the slide agglutination techniques, and the same samples tested for Rh C, c, E, e, and kell1 antigens by immunodifusion gel technique. The results obtained showed that, the c antigen was most common frequency (100%), followed by D antigen occurred (90%), e antigen was found to be (82.5%), and least common were antigen C (67.5%), and E (80%).The kell1 antigen was the least frequency (10%). Keywords: RBCs alloimmunization, Sickle cell disease, Kell1, Blood transfusion
Authors and Affiliations
Ahmed Abdalla Agab Eldour, Tarig Osman Khalafallah, Asaad Mohammed Ahmed Abd Allah Babker, Omer Mohamed Shoaib, Ihab Hamed Nourein Hamed
Keywords
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