From Reperfusion to Regeneration and Beyond
Journal Title: Indian Journal of Cardio Biology & Clinical Sciences - Year 2014, Vol 1, Issue 1
Abstract
The pathophysiology of AMI is a thrombotic occlusion of coronary artery leading to death of heart muscles. The treatment therefore aims at restoration of the blood supply by reopening the artery that can be achieved pharmacologically as well as mechanically. Done in a timely manner these techniques are able to salvage at best only 2-4% of the myocardium at 6 months. The notion of repairing or regenerating lost myocardium via cell based therapies is highly appealing. At present the important tasks ahead of us are efforts to reduce the myocardial perfusion injury as well as regenerate myocardium which may revolutionize the treatment of AMI. This not only will decrease the mortality but also improve long term survival and quality of life.
Authors and Affiliations
Kavita K. Shalia
Keywords
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