FTIR ANALYSIS FOR RETINA ASSOCIATED WITH DIABETIC CHANGES AND TREATMENT WITH OAT
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: Diabetes is known to induce oxidative stress along with deranging various metabolisms. One of the most serious complications of diabetes, a disease that has seen a worldwide increase in the prevalence, is diabetic retinopathy, which is a leading cause of acquired blindness. The aim of this study is to evaluate the effect of oat on the diabetic-induced oxidative stress and if this can attenuate the development of diabetic retinopathy.Methods: Changes on retina structure were performed by using the application of Fourier transform infrared spectroscopy.Results: The results demonstrated that diabetic retinopathy was associated with changes on the retina structure which appear after received a single dose of streptozotocin (STZ) 60 mg/kg. These changes clearly appeared in the NH-OH, CH and fingerprint regions. The use of oat in case of diabetic was associated with different beneficial effects on the retina constituents, as showed by the changes toward control of the same Fourier transform infrared spectroscopy bands.Conclusion: Oat can be considered as a novel treatment modality for diabetic retinopathy and further studies is required to optimize dosing and formulations that are maximally effective.Â
Authors and Affiliations
Eman M. Aly
Keywords
Related Articles
- EP ID EP578296
- DOI -
- Views 39
- Downloads 0
GC-MS ANALYSIS, HPTLC FINGERPRINT PROFILE AND DPPH FREE RADICAL SCAVENGING ASSAY OF METHANOL EXTRACT OF MARTYNIA ANNUA LINN SEEDS
Objective: To investigate the photochemical constituents present in methanol extract of martynia annua seeds using Gas Chromatography-Mass Spectroscopy(GC-MS), High-Performance Thin–Layer Chromatography(HPTLC) analysis a...
A RAPID RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATIVE ESTIMATION OF DABIGATRAN ETEXILATE MESYLATE IN CAPSULES
Objective: To develop a rapid, sensitive, accurate, precise and linear Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method and validate as per ICH guidelines for the quantitative estimation of Dabigatr...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS QUANTITATIVE ESTIMATION OF METRONIDAZOLE AND NALIDIXIC ACID IN TABLETS
Objective: To develop an accurate, precise and linear Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method for simultaneous quantitative estimation of Metronidazole and Nalidixic acid in tablets and val...
COMPARATIVE ANALYSIS OF POTENTIALITY OF ESCULIN AND HINOKITOL (Î’-THUJAPLICIN) AS ANTI-PARKINSONISM DRUGS: A PILOT IN SILICO STUDY
Objective: Parkinson’s disease (PD) is a leading cause of mental disability and death worldwide. Even though there are many advances in drug development against PD, a potent low dosage drug with fewer side effects are...
POTENTIAL HEALING EFFECTS OF HIBISCUS SABDARIFFA L. FLOWERS ON ARTHRITIS
Objective: The present study has been focused to assess the anti-inflammatory activity and healing effects of the aqueous extract of Hibiscus sabdariffa L. Flowers on induced arthritis in mice and compare it with meloxic...