Functional characterization of the cAMP-binding proteins Epac in cardiac myocytes.
Journal Title: Pharmacological Reports - Year 2009, Vol 61, Issue 1
Abstract
The cyclic AMP (cAMP)-binding proteins, Epac, are guanine nucleotide exchange factors for the Ras-like small GTPases. Since their discovery in 1998 and with the development of specific Epac agonists, many data in the literature have illustrated their critical role in multiple cellular events mediated by the second messenger cAMP. Given the importance of cAMP in cardiovascular physiology and physiopathology, there is a growing interest to delineate the role of these multi-domain Epac in the cardiovascular system. This review will focus on recent pharmacological and biochemical studies aiming at understanding the role of Epac in cardiomyocyte signaling and hypertrophy.
Authors and Affiliations
Mélanie Métrich, Eric Morel, Magali Berthouze, Laetitia Pereira, Philippe Charron, Ana-Maria Gomez, Frank Lezoualc'h
Keywords
Related Articles
- EP ID EP149806
- DOI -
- Views 89
- Downloads 0
Induction of caspase 3 activity, bcl-2 bax and p65 gene expression modulationin human acute promyelocytic leukemia HL-60 cells by doxorubicin with amifostine.
The influence of amifostine alone and in combination with doxorubicin,cytarabine, and etoposide on the cell growth and on bcl-2, bax and p65 gene expression was investigatedin human acute promyelocytic leukemia cell line...
Some drugs inhibit in vitro hydratase and esterase activities of human carbonic anhydrase-I and II.
In this study, we determined the in vitro inhibitory effects of ceftriaxone sodium, imipenem and ornidazole on hydratase and esterase activities of human erythrocyte carbonic anhydrase-I and II isozymes (CA I and II). Hu...
Inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity reaction by antidepressant drugs.
Background: Contact hypersensitivity (CHS) induced by a topical application of hapten - 2,4-dinitrofluorobenzene (DNFB), is a T cytotoxic (Tc)1-cell-mediated antigen-specific type of skin inflammation. Recently, it has b...
Structure, stability, and antiplatelet activity of O-acyl derivatives of salicylic acid and lipophilic esters of acetylsalicylate.
The anti-thrombotic activity of acetylsalicylic acid (ASA) has been shown to be due to specific irreversible acetylation of blood platelet cyclooxygenase. The aim of our study was to investigate the associations between...
Effect of prior stress on interleukin-1β and HPA axis responses to acute stress.
Interleukin-1β (IL-1β) level is modulated during multiple stress reactions both in brain structures involved in hypothalamic-pituitary-adrenal (HPA) axis regulation and peripheral systems. Multiple distinct stressors ind...