Functional Status of Mitochondrial Pore in the Brain of Laboratory Rats Subjected to Prolonged Emotional Stress
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2011, Vol 7, Issue 4
Abstract
We have studied the functional status of the mitochondrial membrane pore in the brain of laboratory rats under the stress caused by 30-day isolation and violation of diurnal cycles. It has been established that the functional status of the MMTP changes under the stress. Particularly, the MPTP is activated as the pore opens affected by an increased concentration of cytoplasmic Са[sup]2+[/sup] and reduced content of mitochondrial Са[sup]2+[/sup]. It has been suggested that the Са[sup]2+[/sup]-induced opening of the pore is a result of the intensified oxidative processes in the brain, as a result of energy deficiency and a reduced activity of anti-oxidative enzymes.
Authors and Affiliations
G. Burjanadze, K. Menabde, M. Gavashelidze, Z. Kuchukasvili, N. Koshoridze
Keywords
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