Fungemia in Immunocompromised Patients (Hematological Malignant and Hematopoietic Stem Cell Transplant Patients during Febrile Neutropenia)
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 71, Issue 5
Abstract
<span>Background: </span><span>Fungal infections are a major cause of morbidity and mortality among febrile neutropenic patients.<br /> The choice of empiric antifungal regimen is based on susceptibility pattern of locally prevalent pathogens.<br /> </span><span>Objectives: </span><span>to determine fungemia, identify fungal spectrum and their antifungal susceptibility pattern.<br /> </span><span>Methods: </span><span>From 150 hematological malignant and hematopoietic stem cell transplant patients during febrile neutropenia, blood cultures (B.C) were processed. </span><span>Results: </span><span>Eight fungal isolates (5.3%) were recovered which found to be represented by </span><span>candida </span><span>spp. Five of them were non albicans </span><span>Candida (</span><span>62.5%) and three of them were </span><span>Candida albicans </span><span>(37.5%). </span><span>C. parapsilosis </span><span>resulted in the most frequent </span><span>Candida non albicans </span><span>(CnA) species (37.5%). All </span><span>C. parapsilosis </span><span>strains were isolated from patients with vascular catheters. </span><span>C. krusei </span><span>fungemia generally occur in patients with previous exposure to fluconazoles. All species of </span><span>Candida </span><span>were sensitive to amphoterecin B, echinocandins and voriconazole. Persistent fever for prolonged duration and prolonged broad spectrum antibiotic use were statistically significant risk factors for developing fungemia. Also extent of neutropenia, duration of chemotherapy, immunosuppressive therapy, altered mucosal barriers and presence of central venous lines were considered major risk factors for development of fungemia. </span><span>Conclusion: </span><span>The current study was limited by method of diagnosis and low sample size in a single center experience. Furthermore review of the epidemiology of fungemia which was represented by candidemia at our institution revealed the percentage of candidemia was 5.3% and </span><span>non albicans Candida </span><span>species were the predominant isolates. </span><span>Recommendations: </span><span>The choice of therapy in neutropenic patients should be formulated based on local antimicrobial susceptibility of these organisms. Close monitoring of fungal infection in patients receiving broad-spectrum antibiotics is mandatory.<br /> </span>
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP583954
- DOI -
- Views 79
- Downloads 0
Systemic Review: Effect Of Weight Reduction On Decreasing Of BP
<span>Background: </span><span>Lowering the blood pressure could decrease the risks of cardiovascular morbidity and mortality rates and showed an association between lowering the body weight and management of blood press...
Driving Eligibility among Epilepsy Patients in Saudi Arabia Ali Jaffr Al Taho
Background: epilepsy is prevalent neurological disorder in Saudi Arabia and listed as temporary or permanent driving interdiction. In line with other countries rules and requirements, would be safer, for the patient and...
Clinical Patterns of Facial Aging among Egyptian Females
<strong>Background:</strong> the skin displays the most visible manifestations of aging. Research interest in aging process has grown and people are becoming obsessed with looking young. The face has received most of the...
Primary Health Care Physicians' Knowledge, Attitude and Practice towards Evidence-Based Medicine in Tabuk City, KSA
<strong>Background: </strong>Evidence-based medicine (EBM) is an essential component of modern medical practice and crucial for patient safety and high-quality health care services. <strong>Objectives: </strong>This stud...
Accuracy of Lung Ultrasonography in Diagnosis of Community Acquired Pneumonia as Compared to Chest X-Ray in Pediatric Age Group
<strong>Objective: </strong>It was aimed at investigating the role of lung ultrasonography in assessment of pneumonia as compared to chest x-ray in pediateric age group. <strong>Purpose: </strong>to evaluate the ultrasou...