Fusion gene bcr-abl: from etiopathogenesis to the management of Chronic Myeloid Leukemia
Journal Title: Jurnal Kedokteran dan Kesehatan Indonesia - Year 2017, Vol 8, Issue 1
Abstract
Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm. CML is relative frequent disorder. Most of CML patients have Philadelphia chromosome (Ph),which is derived from a reciprocal translocation between chromosome 9 and 22, t(9;22)(q34;ql1), generating the BCR-ABLfusion gene. In general, there are 3 breakpoint cluster regions in BCR gene : mayor(M-bcr), minor (m-bcr) and micro (ยต-bcr). The BCR-ABL gene encodes proteins that vary in size depending on the breakpoint in the BCR gene. However, these proteins share a high tyrosine kinase activity. In the absence of activating stimuli, BCR-ABL tyrosine kinase able to transferphosphate from ATP (autophosphorilation) to tyrosine residues on various substrates in the cell. It actives intracelluler signaling pathways. These pathways cause increase proliferation or decrease apoptosis and differentiation of a hematopoietic stem cell; and defect in adherence of myeloid progenitors to marrow stroma resulting in CML. These discoveries determined that BCR-ABL fusion gene is critical event in etiopathogenesis of CML and a ideal target for therapy. Therapy of CML patients with BCR-ABL fusion gene-positif is by block autophosphorilation mechanism by Tyrosine Kinase Inhibitor (TKI), example imatinib. Molecular method to detect BCR-ABL transcript is necessary for monitoring response to TKI in CML pateints.
Authors and Affiliations
Tri Agusti Sholikah
Keywords
Related Articles
- EP ID EP383381
- DOI 10.20885/JKKI.Vol8.Iss1.art5
- Views 118
- Downloads 0
Clinical symptoms and risk factors comparison of ischemic and hemorrhagic stroke
Backround: It is very important to know and detect various stroke symptoms because stroke is an emergency condition. Lack of knowledge about stroke symptoms leads to delay on stroke treatment. Objective: The aim of this...
Potency of Xanthone Derivatives as antibacterial agent against Methicillin-Resistant Staphylococcus Aureus (MRSA)
Antibiotic resistance is increasing worldwide and becoming a serious problem for the treatment of patients and also affecting their economy. One instance of bacteria that is resistant to the antibiotic is Methicillin-Res...
Cardenolides source and therapeutic effects
No Abstract
Peripartum Cardiomyopathy (PPCM) : Case Report and Review of Literatures
Introduction: Peripartum cardiomyopathy (PPCM) is a disease characterized by an enlargement of the heart muscle wall. The disease occurs in the last month of pregnancy up to 5 months postpartum, with no previous history...
Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats
Background: The exposure of free radicals can induce oxidative stress. In the liver, this process will cause impaired liver function. Oxidative stress can be inhibited by antioxidants. Arrowroot tubers (Maranta arundinac...