Ganciclovir use evaluation in kidney transplantation
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2016, Vol 1, Issue 2
Abstract
Objective: In this study, we evaluated certain aspects of the usage and administration of one lifesaving, high cost medication, i.e., Ganciclovir for the prevention and treatment of cytomegalovirus (CMV) infection in transplant patients. Methods: This study was performed from 2013 to 2015 by conducting a medication use evaluation (MUE) program in the kidney transplantation departments of two tertiary care hospitals in Isfahan, Iran. The MUE criteria for the drug were developed by applying drug information references. In every category of data, the number (percent) of cases, in which drug therapy was in accordance with the predetermined criteria, was calculated. Findings: During the study period, 67 cases were observed. The only documented drug interaction was the minor interaction of Ganciclovir with mycophenolate mofetil in 77% of the patients. In all patients, intravenous (IV) infusion was the route of administration, mainly in the peripheral veins. Four patients showed adverse drug reaction, which leads to Ganciclovir discontinuation. Ganciclovir was administered despite contraindication in 34.3% of the patients. Conclusion: In this study, we faced a relatively unacceptable situation, in which Ganciclovir is handled somehow inappropriately. It seems necessary to develop an updated local guideline to approximate the administering pattern of such costly medications to standard protocols.
Authors and Affiliations
Saiyad Al Husain
Keywords
Related Articles
- EP ID EP492154
- DOI -
- Views 157
- Downloads 0
A Survey of Knowledge of Antiseptic and Disinfectant Use Among Interns in a Tertiary Care Hospital.
Objective - To find the knowledge of the interns about the use of antiseptics and disinfectants. Methods - This questionnaire-based cross-sectional study was conducted in a tertiary-care government hospital among medial...
A Statistical Analysis on Association of Tissue Hormonic Imaging and Superior Image Quality
Introduction: Tissue harmonic imaging (THI) is recently introduced as a new imaging technology to improve the ultrasound image quality. Our study aims at to evaluate the statistical association of superior image quality...
Prognostic Importance of WBC Count in Acute Myocardial Infraction.
Background: An increase in white blood cell (WBC) count and a high plasma glucose level are frequently observed in patients with acute myocardial infarction. WBC count is a simple marker of inflammation, which plays an i...
Correlation between Dyslipidemia and Markers of Inflammation in Pre-Diabetic and Diabetic Population.
Diabetic mellitus is associated with cardiovascular risks that are further aggregated by the presence of dyslipidemia and alteration in inflammatory pathophysiology. Early management dyslipidemia and improvement of dearr...
Study of Serum Lipid Profile in Beta-Thalassemia Major Patients
Background: Beta-thalassemia is the commonest single-gene disorder in the Indian population. Beta thalassemia major is caused by complete absence of beta globin chain production resulting from reduced synthesis of one or...