GAS CHROMATOGRAPHY TROUBLESHOOTING STRATEGY FOR ANALYTICAL CHEMISTRY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
The most utilized of all the chromatographic techniques is gas chromatography. This technique gives good precision and accuracy. Essentially a gas chromatography separates of a gaseous mixture in a column and detects the components as they are eluted. The response of the detector is plotted as a function of time & carrier gas volume on a strip chart recorder. Gas chromatography is one of the sole forms of chromatography that does not utilize the mobile phase for interacting with the analyte. It can be configured for analysis of specific compounds using a wide choice of options. GC is a very well- established technique for determination of residual solvents, non chromophoric impurities in drug substance, drug product and environmental contaminant identification. Troubleshooting GC instrumentation and separation require a fundamental understanding of how the instrument functions and how the separation works. This article helps the reader to understand the relationship between the problems and remedy. The objective of this work is it serves as both troubleshooting guide and a GC learning tool.
Authors and Affiliations
Sunitha Panthagada , Lavanya Kandiboti , Anil Appapurapu , L. K Kanthal , Kausik Bhar
Keywords
Related Articles
- EP ID EP119761
- DOI -
- Views 79
- Downloads 0
NON-BEHAVIORAL MODELS OF PSYCHOSIS
Animal models have become indispensible tools for discovering new medicines and in the analysis of multitude of causes, bio-markers and pathophysiological changes, which bring about symptoms characteristics of a specific...
FORMULATION AND EVALUATION OF RANITIDINE LOADED CHITOSAN MICROSPHERES
The present study aimed at the formulation of Ranitidine hydrochloride loaded chitosan microspheres to prolong the release rate so as to decrease the necessity of multiple dosage and to increase bioavailability. Ranitidi...
BASKETFUL BENEFITS OF PAPAYA
Papaya (Carica papaya linn) is well known for its exceptional nutritional and medicinal properties throughout the world. From the times immemorial, the whole Papaya plant including its leaves, seeds, ripe and unripe frui...
ANTI-ALZHEIMER POTENTIAL OF ORANGE JUICE
Orange (Citrus sinensis) is well known for its nutritional and medicinal properties throughout the world. This study was undertaken to test the effect of orange juice on the memory of mice. A total of 228 mice divided in...
FORMULATION AND EVALUATION OF BACLOFEN CONTROLLED POROSITY OSMOTIC PUMP TABLETS
In the present study, attempts were made to develop and evaluate the controlled porosity osmotic pump (CPOP) based drug delivery system of sparingly water soluble drug Baclofen. Formulation variables, such as, levels of...